Detailed information of TA system TA123952

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 96084..96609
• Replicon: plasmid pCFSAN086834
• Accession: NZ_CP039444
• Organism: Salmonella enterica subsp. enterica serovar Infantis strain VNSEC002

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: A0A5Y5FBU7
• Locus tag: E8N15_RS23390
• Protein ID: WP_023994134.1
• Coordinates: 96304..96609 (+)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: A0A5T8X4Y4
• Locus tag: E8N15_RS23385
• Protein ID: WP_023994135.1
• Coordinates: 96084..96302 (+)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E8N15_RS23350	91116..91880	+	765	WP_023994141.1	minor fimbrial protein	-
E8N15_RS23355	92083..92673	+	591	WP_023994140.1	hypothetical protein	-
E8N15_RS23360	92739..92951	+	213	WP_023994139.1	PefI	-
E8N15_RS23365	93212..93373	+	162	WP_001816720.1	hypothetical protein	-
E8N15_RS23370	93399..94247	+	849	WP_023994138.1	SdiA-regulated domain-containing protein	-
E8N15_RS23375	94817..95233	-	417	WP_023994137.1	type II toxin-antitoxin system VapC family toxin	-
E8N15_RS23380	95230..95460	-	231	WP_023994136.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
E8N15_RS23385	96084..96302	+	219	WP_023994135.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
E8N15_RS23390	96304..96609	+	306	WP_023994134.1	type II toxin-antitoxin system toxin CcdB	Toxin
E8N15_RS23395	96611..96901	+	291	WP_023994133.1	hypothetical protein	-
E8N15_RS23400	96898..97248	+	351	Protein_110	3'-5' exonuclease	-
E8N15_RS23405	97274..97360	+	87	Protein_111	cytoplasmic protein	-
E8N15_RS23410	97350..98065	-	716	Protein_112	transposase	-
E8N15_RS23415	99347..99883	+	537	WP_023994130.1	fimbrial protein	-
E8N15_RS23420	99936..100667	+	732	WP_023994129.1	fimbria/pilus periplasmic chaperone	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..321889	321889

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Antitoxin

• Toxin YoeB (5-84)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 13091.77 Da
• Isoelectric Point: 12.8043

>T123952 WP_023994134.1 NZ_CP039444:96304-96609 [Salmonella enterica subsp. enterica serovar Infantis]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 306 bp

>T123952 NZ_CP039444:96304-96609 [Salmonella enterica subsp. enterica serovar Infantis]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 9374.72 Da
• Isoelectric Point: 12.6573

>AT123952 WP_023994135.1 NZ_CP039444:96084-96302 [Salmonella enterica subsp. enterica serovar Infantis]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 219 bp

>AT123952 NZ_CP039444:96084-96302 [Salmonella enterica subsp. enterica serovar Infantis]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Structures

Toxin

• AlphaFold DB: A0A5Y5FBU7

Antitoxin

• AlphaFold DB: A0A5T8X4Y4