Detailed information of TA system TA123951

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vagCD/VapC-VagC
• Location: 94817..95460
• Replicon: plasmid pCFSAN086834
• Accession: NZ_CP039444
• Organism: Salmonella enterica subsp. enterica serovar Infantis strain VNSEC002

Toxin (Protein)

• Gene name: vagD
• Uniprot ID: A0A5T8FJ24
• Locus tag: E8N15_RS23375
• Protein ID: WP_023994137.1
• Coordinates: 94817..95233 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: A0A5T3Q059
• Locus tag: E8N15_RS23380
• Protein ID: WP_023994136.1
• Coordinates: 95230..95460 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E8N15_RS23345	90297..91088	+	792	WP_023994142.1	F4 (K88) fimbria minor subunit FaeH	-
E8N15_RS23350	91116..91880	+	765	WP_023994141.1	minor fimbrial protein	-
E8N15_RS23355	92083..92673	+	591	WP_023994140.1	hypothetical protein	-
E8N15_RS23360	92739..92951	+	213	WP_023994139.1	PefI	-
E8N15_RS23365	93212..93373	+	162	WP_001816720.1	hypothetical protein	-
E8N15_RS23370	93399..94247	+	849	WP_023994138.1	SdiA-regulated domain-containing protein	-
E8N15_RS23375	94817..95233	-	417	WP_023994137.1	type II toxin-antitoxin system VapC family toxin	Toxin
E8N15_RS23380	95230..95460	-	231	WP_023994136.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
E8N15_RS23385	96084..96302	+	219	WP_023994135.1	type II toxin-antitoxin system antitoxin CcdA	-
E8N15_RS23390	96304..96609	+	306	WP_023994134.1	type II toxin-antitoxin system toxin CcdB	-
E8N15_RS23395	96611..96901	+	291	WP_023994133.1	hypothetical protein	-
E8N15_RS23400	96898..97248	+	351	Protein_110	3'-5' exonuclease	-
E8N15_RS23405	97274..97360	+	87	Protein_111	cytoplasmic protein	-
E8N15_RS23410	97350..98065	-	716	Protein_112	transposase	-
E8N15_RS23415	99347..99883	+	537	WP_023994130.1	fimbrial protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..321889	321889

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 20475.56 Da
• Isoelectric Point: 5.5500

>T123951 WP_023994137.1 NZ_CP039444:c95233-94817 [Salmonella enterica subsp. enterica serovar Infantis]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 417 bp

>T123951 NZ_CP039444:c95233-94817 [Salmonella enterica subsp. enterica serovar Infantis]
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Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 11350.61 Da
• Isoelectric Point: 5.5500

>AT123951 WP_023994136.1 NZ_CP039444:c95460-95230 [Salmonella enterica subsp. enterica serovar Infantis]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 231 bp

>AT123951 NZ_CP039444:c95460-95230 [Salmonella enterica subsp. enterica serovar Infantis]
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Structures

Toxin

• AlphaFold DB: A0A5T8FJ24

Antitoxin

• AlphaFold DB: A0A5T3Q059