Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 272328..272971 Replicon plasmid pCFSAN086835
Accession NZ_CP039442
Organism Salmonella enterica subsp. enterica serovar Infantis strain VNSEC003

Toxin (Protein)


Gene name vagD Uniprot ID B1LRW4
Locus tag E8N16_RS24190 Protein ID WP_001044768.1
Coordinates 272328..272744 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D2WFK3
Locus tag E8N16_RS24195 Protein ID WP_001261287.1
Coordinates 272741..272971 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E8N16_RS24175 268827..269417 - 591 WP_000194575.1 hypothetical protein -
E8N16_RS24180 269417..269674 - 258 WP_000343085.1 hypothetical protein -
E8N16_RS24185 270028..272166 + 2139 WP_000350635.1 AAA family ATPase -
E8N16_RS24190 272328..272744 - 417 WP_001044768.1 type II toxin-antitoxin system VapC family toxin Toxin
E8N16_RS24195 272741..272971 - 231 WP_001261287.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
E8N16_RS24200 273279..274844 + 1566 WP_000741348.1 AAA family ATPase -
E8N16_RS24205 274901..275770 - 870 WP_000253407.1 hypothetical protein -
E8N16_RS24210 275772..276860 - 1089 WP_000952231.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..321887 321887


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(7-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 20475.56 Da        Isoelectric Point: 5.5500

>T123948 WP_001044768.1 NZ_CP039442:c272744-272328 [Salmonella enterica subsp. enterica serovar Infantis]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 417 bp

>T123948 NZ_CP039442:c272744-272328 [Salmonella enterica subsp. enterica serovar Infantis]
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TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
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TTTTTTTTTTTTTTTTT

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 11350.61 Da        Isoelectric Point: 5.5500

>AT123948 WP_001261287.1 NZ_CP039442:c272971-272741 [Salmonella enterica subsp. enterica serovar Infantis]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 231 bp

>AT123948 NZ_CP039442:c272971-272741 [Salmonella enterica subsp. enterica serovar Infantis]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A606Q844

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QFC4

References