Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 199606..200196 Replicon plasmid pCFSAN086835
Accession NZ_CP039442
Organism Salmonella enterica subsp. enterica serovar Infantis strain VNSEC003

Toxin (Protein)


Gene name pemK Uniprot ID A0A241PXU0
Locus tag E8N16_RS23820 Protein ID WP_023994178.1
Coordinates 199606..199938 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A5T3Q5H6
Locus tag E8N16_RS23825 Protein ID WP_023994179.1
Coordinates 199939..200196 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E8N16_RS23810 195880..198102 + 2223 WP_023994175.1 DEAD/DEAH box helicase -
E8N16_RS23815 198401..199006 - 606 Protein_193 IS481 family transposase -
E8N16_RS23820 199606..199938 - 333 WP_023994178.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
E8N16_RS23825 199939..200196 - 258 WP_023994179.1 hypothetical protein Antitoxin
E8N16_RS23830 200807..203662 + 2856 Protein_196 hypothetical protein -
E8N16_RS23835 203672..204697 - 1026 WP_023994180.1 IS630 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..321887 321887


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(88-134)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 16354.62 Da        Isoelectric Point: 5.5500

>T123947 WP_023994178.1 NZ_CP039442:c199938-199606 [Salmonella enterica subsp. enterica serovar Infantis]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 333 bp

>T123947 NZ_CP039442:c199938-199606 [Salmonella enterica subsp. enterica serovar Infantis]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
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TTTTTTTTTTTTT

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 12675.20 Da        Isoelectric Point: 5.5500

>AT123947 WP_023994179.1 NZ_CP039442:c200196-199939 [Salmonella enterica subsp. enterica serovar Infantis]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFF

Download         Length: 258 bp

>AT123947 NZ_CP039442:c200196-199939 [Salmonella enterica subsp. enterica serovar Infantis]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241PXU0

Antitoxin

Source ID Structure
AlphaFold DB A0A5T3Q5H6

References