Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 165454..166097 Replicon plasmid pCFSAN086835
Accession NZ_CP039442
Organism Salmonella enterica subsp. enterica serovar Infantis strain VNSEC003

Toxin (Protein)


Gene name vagD Uniprot ID A0A5T8FJ24
Locus tag E8N16_RS23610 Protein ID WP_023994137.1
Coordinates 165681..166097 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A5T3Q059
Locus tag E8N16_RS23605 Protein ID WP_023994136.1
Coordinates 165454..165684 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E8N16_RS23570 161031..161567 - 537 WP_023994130.1 fimbrial protein -
E8N16_RS23575 162849..163564 + 716 Protein_145 transposase -
E8N16_RS23580 163554..163640 - 87 Protein_146 cytoplasmic protein -
E8N16_RS23585 163666..164016 - 351 Protein_147 3'-5' exonuclease -
E8N16_RS23590 164013..164303 - 291 WP_023994133.1 hypothetical protein -
E8N16_RS23595 164305..164610 - 306 WP_023994134.1 type II toxin-antitoxin system toxin CcdB -
E8N16_RS23600 164612..164830 - 219 WP_023994135.1 type II toxin-antitoxin system antitoxin CcdA -
E8N16_RS23605 165454..165684 + 231 WP_023994136.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
E8N16_RS23610 165681..166097 + 417 WP_023994137.1 type II toxin-antitoxin system VapC family toxin Toxin
E8N16_RS23615 166667..167515 - 849 WP_023994138.1 SdiA-regulated domain-containing protein -
E8N16_RS23620 167541..167702 - 162 WP_001816720.1 hypothetical protein -
E8N16_RS23625 167963..168175 - 213 WP_023994139.1 PefI -
E8N16_RS23630 168241..168831 - 591 WP_023994140.1 hypothetical protein -
E8N16_RS23635 169034..169798 - 765 WP_023994141.1 minor fimbrial protein -
E8N16_RS23640 169826..170617 - 792 WP_023994142.1 F4 (K88) fimbria minor subunit FaeH -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..321887 321887


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 17834.22 Da        Isoelectric Point: 12.9398

>T123945 WP_023994137.1 NZ_CP039442:165681-166097 [Salmonella enterica subsp. enterica serovar Infantis]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 417 bp

>T123945 NZ_CP039442:165681-166097 [Salmonella enterica subsp. enterica serovar Infantis]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 9887.42 Da        Isoelectric Point: 12.6808

>AT123945 WP_023994136.1 NZ_CP039442:165454-165684 [Salmonella enterica subsp. enterica serovar Infantis]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 231 bp

>AT123945 NZ_CP039442:165454-165684 [Salmonella enterica subsp. enterica serovar Infantis]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5T8FJ24

Antitoxin

Source ID Structure
AlphaFold DB A0A5T3Q059

References