Detailed information of TA system TA123944

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 164305..164830
• Replicon: plasmid pCFSAN086835
• Accession: NZ_CP039442
• Organism: Salmonella enterica subsp. enterica serovar Infantis strain VNSEC003

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: A0A5Y5FBU7
• Locus tag: E8N16_RS23595
• Protein ID: WP_023994134.1
• Coordinates: 164305..164610 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: A0A5T8X4Y4
• Locus tag: E8N16_RS23600
• Protein ID: WP_023994135.1
• Coordinates: 164612..164830 (-)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E8N16_RS23565	160247..160978	-	732	WP_023994129.1	fimbria/pilus periplasmic chaperone	-
E8N16_RS23570	161031..161567	-	537	WP_023994130.1	fimbrial protein	-
E8N16_RS23575	162849..163564	+	716	Protein_145	transposase	-
E8N16_RS23580	163554..163640	-	87	Protein_146	cytoplasmic protein	-
E8N16_RS23585	163666..164016	-	351	Protein_147	3'-5' exonuclease	-
E8N16_RS23590	164013..164303	-	291	WP_023994133.1	hypothetical protein	-
E8N16_RS23595	164305..164610	-	306	WP_023994134.1	type II toxin-antitoxin system toxin CcdB	Toxin
E8N16_RS23600	164612..164830	-	219	WP_023994135.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
E8N16_RS23605	165454..165684	+	231	WP_023994136.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
E8N16_RS23610	165681..166097	+	417	WP_023994137.1	type II toxin-antitoxin system VapC family toxin	-
E8N16_RS23615	166667..167515	-	849	WP_023994138.1	SdiA-regulated domain-containing protein	-
E8N16_RS23620	167541..167702	-	162	WP_001816720.1	hypothetical protein	-
E8N16_RS23625	167963..168175	-	213	WP_023994139.1	PefI	-
E8N16_RS23630	168241..168831	-	591	WP_023994140.1	hypothetical protein	-
E8N16_RS23635	169034..169798	-	765	WP_023994141.1	minor fimbrial protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..321887	321887

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 15030.03 Da
• Isoelectric Point: 5.5500

>T123944 WP_023994134.1 NZ_CP039442:c164610-164305 [Salmonella enterica subsp. enterica serovar Infantis]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 306 bp

>T123944 NZ_CP039442:c164610-164305 [Salmonella enterica subsp. enterica serovar Infantis]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 10761.91 Da
• Isoelectric Point: 5.5500

>AT123944 WP_023994135.1 NZ_CP039442:c164830-164612 [Salmonella enterica subsp. enterica serovar Infantis]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 219 bp

>AT123944 NZ_CP039442:c164830-164612 [Salmonella enterica subsp. enterica serovar Infantis]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Structures

Toxin

• AlphaFold DB: A0A5Y5FBU7

Antitoxin

• AlphaFold DB: A0A5T8X4Y4