Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 57095..58718 Replicon plasmid pCFSAN086837
Accession NZ_CP039438
Organism Salmonella enterica subsp. enterica serovar Newport strain VNSEC023

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag E8N12_RS22930 Protein ID WP_000088046.1
Coordinates 57095..58420 (-) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag E8N12_RS22935 Protein ID WP_024136327.1
Coordinates 58425..58718 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E8N12_RS22900 52156..53160 + 1005 WP_000427619.1 IS110-like element IS5075 family transposase -
E8N12_RS22905 53511..54208 - 698 Protein_67 IS1 family transposase -
E8N12_RS22910 54809..55234 - 426 WP_001043843.1 hypothetical protein -
E8N12_RS22915 55488..56303 - 816 WP_053276223.1 HNH endonuclease -
E8N12_RS22920 56316..56726 - 411 WP_000985911.1 hypothetical protein -
E8N12_RS22925 56828..57034 - 207 WP_000134171.1 hypothetical protein -
E8N12_RS22930 57095..58420 - 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
E8N12_RS22935 58425..58718 - 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
E8N12_RS22940 59322..59714 - 393 WP_000341066.1 hypothetical protein -
E8N12_RS22945 60087..60428 + 342 WP_001151575.1 hypothetical protein -
E8N12_RS22950 60520..60711 + 192 WP_000398480.1 hypothetical protein -
E8N12_RS22955 60761..61042 + 282 WP_000077926.1 hypothetical protein -
E8N12_RS22960 61605..62846 - 1242 WP_001053338.1 VWA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..255725 255725


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 65070.07 Da        Isoelectric Point: 5.5500

>T123943 WP_000088046.1 NZ_CP039438:c58420-57095 [Salmonella enterica subsp. enterica serovar Newport]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 1326 bp

>T123943 NZ_CP039438:c58420-57095 [Salmonella enterica subsp. enterica serovar Newport]
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Antitoxin


Download         Length: 98 a.a.        Molecular weight: 14441.32 Da        Isoelectric Point: 5.5500

>AT123943 WP_024136327.1 NZ_CP039438:c58718-58425 [Salmonella enterica subsp. enterica serovar Newport]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFF

Download         Length: 294 bp

>AT123943 NZ_CP039438:c58718-58425 [Salmonella enterica subsp. enterica serovar Newport]
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Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References