Detailed information of TA system TA123942

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/CC2985(antitoxin)
• Location: 2915122..2915682
• Replicon: chromosome
• Accession: NZ_CP039435
• Organism: Brevundimonas sp. SGAir0440

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: E7T10_RS14335
• Protein ID: WP_137722322.1
• Coordinates: 2915380..2915682 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: E7T10_RS14330
• Protein ID: WP_137722321.1
• Coordinates: 2915122..2915367 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E7T10_RS14305	2910240..2910494	+	255	WP_066626960.1	Txe/YoeB family addiction module toxin	-
E7T10_RS14310	2910499..2911218	+	720	WP_137722317.1	16S rRNA (uracil(1498)-N(3))-methyltransferase	-
E7T10_RS14315	2911288..2912649	+	1362	WP_137722318.1	glutamate--cysteine ligase	-
E7T10_RS14320	2912646..2913383	-	738	WP_137722319.1	hypothetical protein	-
E7T10_RS14325	2913496..2915067	+	1572	WP_137722320.1	response regulator	-
E7T10_RS14330	2915122..2915367	+	246	WP_137722321.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
E7T10_RS14335	2915380..2915682	+	303	WP_137722322.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
E7T10_RS14340	2915679..2916428	+	750	WP_137722323.1	DUF72 domain-containing protein	-
E7T10_RS14345	2916512..2917567	+	1056	WP_174085380.1	NAD(P)-dependent alcohol dehydrogenase	-
E7T10_RS14350	2917713..2918438	+	726	WP_137722324.1	acetoacetyl-CoA reductase	-
E7T10_RS14355	2918488..2919255	+	768	WP_137722325.1	DUF4908 domain-containing protein	-
E7T10_RS14360	2919252..2919980	-	729	WP_137722326.1	hydroxyacylglutathione hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-90)

Antitoxin

• Antitoxin ParD (3-68)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11544.98 Da
• Isoelectric Point: 4.8339

>T123942 WP_137722322.1 NZ_CP039435:2915380-2915682 [Brevundimonas sp. SGAir0440]
MRLTADADHDLANIYVQGVQTFGATQADRYIDDLLRALDRIQDFPKIARLRDDITPAVRAYIFRSHVILYDVEDGDGVVV
VRIRHAHEDWLSPVQEIDQR

Nucleotide

• Length: 303 bp

>T123942 NZ_CP039435:2915380-2915682 [Brevundimonas sp. SGAir0440]
TTGCGGCTCACCGCAGACGCGGATCATGACCTCGCCAACATCTACGTTCAGGGCGTGCAAACGTTCGGCGCGACGCAGGC
CGACCGCTACATCGACGACCTTCTGCGGGCGCTCGACCGCATTCAGGATTTCCCAAAGATCGCCCGACTGCGCGACGACA
TCACGCCCGCCGTCAGAGCCTATATCTTCAGGTCTCATGTAATCCTCTACGATGTGGAAGACGGCGATGGAGTGGTCGTC
GTTCGCATTCGACACGCCCACGAAGACTGGCTGAGCCCGGTTCAGGAGATCGACCAACGATGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9226.54 Da
• Isoelectric Point: 9.9185

>AT123942 WP_137722321.1 NZ_CP039435:2915122-2915367 [Brevundimonas sp. SGAir0440]
MATMNISLPDPMKAWVEEQAKSGRYANTSDVVRDLIRREQVKAEKIANMQRLIDEGRASGISDRTPRQVIDELRAELRKT
A

Nucleotide

• Length: 246 bp

>AT123942 NZ_CP039435:2915122-2915367 [Brevundimonas sp. SGAir0440]
ATGGCGACGATGAACATCTCCCTGCCCGATCCGATGAAGGCCTGGGTCGAGGAACAGGCGAAGTCCGGGCGCTACGCCAA
CACCTCGGACGTGGTGCGCGACCTGATCCGCCGCGAGCAGGTCAAGGCCGAGAAGATCGCCAACATGCAGCGCCTGATCG
ACGAAGGCCGGGCCAGCGGGATCAGCGACCGCACACCTCGACAGGTGATCGACGAATTGCGCGCCGAACTCCGCAAGACC
GCCTGA