Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/CC2985(antitoxin)
Location 2915122..2915682 Replicon chromosome
Accession NZ_CP039435
Organism Brevundimonas sp. SGAir0440

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag E7T10_RS14335 Protein ID WP_137722322.1
Coordinates 2915380..2915682 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag E7T10_RS14330 Protein ID WP_137722321.1
Coordinates 2915122..2915367 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E7T10_RS14305 2910240..2910494 + 255 WP_066626960.1 Txe/YoeB family addiction module toxin -
E7T10_RS14310 2910499..2911218 + 720 WP_137722317.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
E7T10_RS14315 2911288..2912649 + 1362 WP_137722318.1 glutamate--cysteine ligase -
E7T10_RS14320 2912646..2913383 - 738 WP_137722319.1 hypothetical protein -
E7T10_RS14325 2913496..2915067 + 1572 WP_137722320.1 response regulator -
E7T10_RS14330 2915122..2915367 + 246 WP_137722321.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
E7T10_RS14335 2915380..2915682 + 303 WP_137722322.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E7T10_RS14340 2915679..2916428 + 750 WP_137722323.1 DUF72 domain-containing protein -
E7T10_RS14345 2916512..2917567 + 1056 WP_174085380.1 NAD(P)-dependent alcohol dehydrogenase -
E7T10_RS14350 2917713..2918438 + 726 WP_137722324.1 acetoacetyl-CoA reductase -
E7T10_RS14355 2918488..2919255 + 768 WP_137722325.1 DUF4908 domain-containing protein -
E7T10_RS14360 2919252..2919980 - 729 WP_137722326.1 hydroxyacylglutathione hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-90)

Antitoxin

Antitoxin ParD

(3-68)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11544.98 Da        Isoelectric Point: 4.8339

>T123942 WP_137722322.1 NZ_CP039435:2915380-2915682 [Brevundimonas sp. SGAir0440]
MRLTADADHDLANIYVQGVQTFGATQADRYIDDLLRALDRIQDFPKIARLRDDITPAVRAYIFRSHVILYDVEDGDGVVV
VRIRHAHEDWLSPVQEIDQR

Download         Length: 303 bp

>T123942 NZ_CP039435:2915380-2915682 [Brevundimonas sp. SGAir0440]
TTGCGGCTCACCGCAGACGCGGATCATGACCTCGCCAACATCTACGTTCAGGGCGTGCAAACGTTCGGCGCGACGCAGGC
CGACCGCTACATCGACGACCTTCTGCGGGCGCTCGACCGCATTCAGGATTTCCCAAAGATCGCCCGACTGCGCGACGACA
TCACGCCCGCCGTCAGAGCCTATATCTTCAGGTCTCATGTAATCCTCTACGATGTGGAAGACGGCGATGGAGTGGTCGTC
GTTCGCATTCGACACGCCCACGAAGACTGGCTGAGCCCGGTTCAGGAGATCGACCAACGATGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9226.54 Da        Isoelectric Point: 9.9185

>AT123942 WP_137722321.1 NZ_CP039435:2915122-2915367 [Brevundimonas sp. SGAir0440]
MATMNISLPDPMKAWVEEQAKSGRYANTSDVVRDLIRREQVKAEKIANMQRLIDEGRASGISDRTPRQVIDELRAELRKT
A

Download         Length: 246 bp

>AT123942 NZ_CP039435:2915122-2915367 [Brevundimonas sp. SGAir0440]
ATGGCGACGATGAACATCTCCCTGCCCGATCCGATGAAGGCCTGGGTCGAGGAACAGGCGAAGTCCGGGCGCTACGCCAA
CACCTCGGACGTGGTGCGCGACCTGATCCGCCGCGAGCAGGTCAAGGCCGAGAAGATCGCCAACATGCAGCGCCTGATCG
ACGAAGGCCGGGCCAGCGGGATCAGCGACCGCACACCTCGACAGGTGATCGACGAATTGCGCGCCGAACTCCGCAAGACC
GCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References