Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yoeB-relE/YoeB-RelB
Location 2909986..2910494 Replicon chromosome
Accession NZ_CP039435
Organism Brevundimonas sp. SGAir0440

Toxin (Protein)


Gene name yoeB Uniprot ID A0A4P8QC21
Locus tag E7T10_RS14305 Protein ID WP_066626960.1
Coordinates 2910240..2910494 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name relE Uniprot ID A0A4P8QCA2
Locus tag E7T10_RS14300 Protein ID WP_066626962.1
Coordinates 2909986..2910243 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E7T10_RS14275 2905380..2905598 + 219 WP_039244779.1 helix-turn-helix transcriptional regulator -
E7T10_RS14280 2905810..2906226 + 417 WP_137722315.1 DoxX family protein -
E7T10_RS14285 2906402..2906884 + 483 WP_039244783.1 MerR family DNA-binding transcriptional regulator -
E7T10_RS14290 2906888..2908672 + 1785 WP_045809789.1 acyl-CoA dehydrogenase C-terminal domain-containing protein -
E7T10_RS14295 2908769..2909932 + 1164 WP_137722316.1 acyl-CoA dehydrogenase family protein -
E7T10_RS14300 2909986..2910243 + 258 WP_066626962.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
E7T10_RS14305 2910240..2910494 + 255 WP_066626960.1 Txe/YoeB family addiction module toxin Toxin
E7T10_RS14310 2910499..2911218 + 720 WP_137722317.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
E7T10_RS14315 2911288..2912649 + 1362 WP_137722318.1 glutamate--cysteine ligase -
E7T10_RS14320 2912646..2913383 - 738 WP_137722319.1 hypothetical protein -
E7T10_RS14325 2913496..2915067 + 1572 WP_137722320.1 response regulator -
E7T10_RS14330 2915122..2915367 + 246 WP_137722321.1 type II toxin-antitoxin system ParD family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9946.37 Da        Isoelectric Point: 9.9687

>T123941 WP_066626960.1 NZ_CP039435:2910240-2910494 [Brevundimonas sp. SGAir0440]
MNVLFTARAWSQYTEWQDTDRKALKKLNTLIKECQRTPFTGSGKPEPLKGELAGFWSRRIDQEHRLVYRATQTGLEIVQC
RFHY

Download         Length: 255 bp

>T123941 NZ_CP039435:2910240-2910494 [Brevundimonas sp. SGAir0440]
ATGAACGTCCTCTTCACGGCCCGCGCCTGGTCTCAATATACCGAGTGGCAGGATACGGACCGCAAAGCGCTCAAGAAGCT
GAACACGCTCATCAAGGAATGCCAACGAACCCCGTTTACAGGCTCCGGCAAGCCCGAGCCATTGAAGGGTGAATTGGCGG
GATTTTGGTCGCGACGTATCGATCAGGAGCATCGCCTAGTCTATCGCGCGACCCAGACCGGCTTGGAAATCGTCCAATGC
CGCTTTCACTATTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9364.50 Da        Isoelectric Point: 4.3566

>AT123941 WP_066626962.1 NZ_CP039435:2909986-2910243 [Brevundimonas sp. SGAir0440]
MNAMSVTDLRKNLASAIDRVTADHDYTIITREGGKPAAVLMSLEDFASWQETEYLLRSPANREALRASIAELEAGGGQVR
ELIEE

Download         Length: 258 bp

>AT123941 NZ_CP039435:2909986-2910243 [Brevundimonas sp. SGAir0440]
ATGAACGCGATGTCCGTCACCGATCTCCGCAAGAACCTCGCATCGGCCATCGACCGGGTGACGGCGGATCATGACTACAC
CATCATCACGCGCGAAGGCGGAAAGCCGGCGGCGGTGCTGATGTCGCTGGAGGATTTCGCCTCGTGGCAGGAGACGGAGT
ATCTGCTGCGCAGCCCGGCCAACCGCGAAGCGCTGCGAGCCTCGATTGCCGAACTTGAAGCGGGTGGCGGCCAGGTGCGC
GAACTGATCGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P8QC21

Antitoxin

Source ID Structure
AlphaFold DB A0A4P8QCA2

References