Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/ElaA-DUF1778
Location 40105..40865 Replicon plasmid unnamed
Accession NZ_CP039405
Organism Escherichia coli strain 377323_2f

Toxin (Protein)


Gene name tacT Uniprot ID A0A8H9BF00
Locus tag E9097_RS24970 Protein ID WP_062859951.1
Coordinates 40105..40593 (-) Length 163 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag E9097_RS24975 Protein ID WP_073534343.1
Coordinates 40581..40865 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E9097_RS24950 36680..37540 + 861 WP_062859948.1 alpha/beta hydrolase -
E9097_RS24960 38499..39122 - 624 WP_062859950.1 proQ/FINO family protein -
E9097_RS24965 39182..39592 - 411 Protein_48 serine acetyltransferase -
E9097_RS24970 40105..40593 - 489 WP_062859951.1 GNAT family N-acetyltransferase Toxin
E9097_RS24975 40581..40865 - 285 WP_073534343.1 DUF1778 domain-containing protein Antitoxin
E9097_RS24995 41780..42637 - 858 WP_062859953.1 incFII family plasmid replication initiator RepA -
E9097_RS25000 42630..42704 - 75 WP_062859978.1 RepA leader peptide Tap -
E9097_RS25010 42947..43195 - 249 WP_000083839.1 replication regulatory protein RepA -
E9097_RS25015 43435..44025 - 591 WP_062859954.1 DUF2726 domain-containing protein -
E9097_RS25020 44064..44273 - 210 WP_001299729.1 hemolysin expression modulator Hha -
E9097_RS25025 44319..44780 - 462 Protein_56 thermonuclease family protein -
E9097_RS25030 45026..45238 - 213 WP_062859955.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - bfpK / bfpJ / bfpI / bfpH / bfpP / bfpF / bfpE / bfpD / bfpU / bfpC / bfpB / bfpG / bfpA 1..85191 85191


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(27-152)

Antitoxin

Vibrio phage ICP1, Orf50

(12-88)


Sequences

Toxin        


Download         Length: 163 a.a.        Molecular weight: 17614.34 Da        Isoelectric Point: 9.8566

>T123930 WP_062859951.1 NZ_CP039405:c40593-40105 [Escherichia coli]
MGGVTAPEPLSSFHQAAEFVSGEAVLDDWLKQKGLKNQALGATRTFVVCRKGSQQIVGFYSLATGSVNHTEAAGNLRRNM
PDPIPVIILARLAVDVSFRGKGLGADLLHDAVCRCYRVAENIGVRAIMVHALTENAKQFYIHHGFKPSKSQEQTLFLKLP
GK

Download         Length: 489 bp

>T123930 NZ_CP039405:c40593-40105 [Escherichia coli]
ATGGGAGGTGTAACAGCACCAGAACCTTTGTCCTCATTTCATCAGGCCGCTGAATTTGTCAGTGGTGAAGCTGTGCTTGA
TGACTGGTTAAAGCAGAAGGGGCTGAAAAATCAGGCTCTCGGAGCCACACGGACTTTTGTTGTATGCAGAAAAGGTTCGC
AACAAATAGTCGGTTTTTACTCTCTGGCCACCGGGAGTGTTAATCATACAGAGGCTGCAGGCAACCTTCGGCGCAATATG
CCAGACCCTATACCTGTTATTATACTTGCACGCCTGGCCGTTGATGTGTCATTCCGTGGAAAAGGGCTTGGCGCAGATTT
ACTTCATGATGCTGTTTGTCGTTGTTACAGGGTTGCCGAAAATATCGGTGTGCGTGCAATTATGGTTCATGCGCTTACGG
AAAACGCAAAACAGTTTTATATTCATCATGGTTTTAAGCCATCAAAAAGCCAGGAGCAAACATTGTTTCTTAAACTCCCC
GGCAAGTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10947.62 Da        Isoelectric Point: 4.7037

>AT123930 WP_073534343.1 NZ_CP039405:c40865-40581 [Escherichia coli]
MIYGGFMKSGVQLNLRARESQRILIDTAAEILHKSRTDFILEMACKAAEDIILDRRVFNFNDRQYEEFIEMLDAPVADET
AIEKLLARKPQWEV

Download         Length: 285 bp

>AT123930 NZ_CP039405:c40865-40581 [Escherichia coli]
ATGATATACGGAGGCTTTATGAAATCAGGTGTTCAGCTCAATCTCAGGGCAAGAGAATCTCAGCGGATACTCATTGATAC
CGCTGCAGAAATTCTTCATAAGTCGCGTACAGACTTCATTCTGGAAATGGCCTGTAAAGCTGCTGAAGATATTATTCTTG
ACCGGCGGGTGTTTAATTTTAATGACAGGCAATATGAAGAGTTCATCGAAATGCTTGATGCTCCGGTTGCTGATGAGACT
GCCATCGAAAAACTGCTGGCGAGGAAACCTCAATGGGAGGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References