Detailed information of TA system TA123906

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): shpAB/BrnT-BrnA
• Location: 798692..799200
• Replicon: chromosome
• Accession: NZ_CP039404
• Organism: Escherichia coli strain 377323_2f

Toxin (Protein)

• Gene name: shpA
• Uniprot ID: -
• Locus tag: E9097_RS03985
• Protein ID: WP_001534843.1
• Coordinates: 798692..798901 (+)
• Length: 70 a.a.

Antitoxin (Protein)

• Gene name: shpB
• Uniprot ID: A0A0V9L4L3
• Locus tag: E9097_RS03990
• Protein ID: WP_000063161.1
• Coordinates: 798898..799200 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E9097_RS03955	794201..795613	-	1413	WP_024225547.1	PLP-dependent aminotransferase family protein	-
E9097_RS03960	795790..795954	+	165	WP_001350373.1	DUF1127 domain-containing protein	-
E9097_RS03965	795997..796335	-	339	WP_000132618.1	endoribonuclease SymE	-
E9097_RS03970	796550..797218	-	669	Protein_740	DUF3387 domain-containing protein	-
E9097_RS03975	797212..797385	-	174	Protein_741	SAM-dependent DNA methyltransferase	-
E9097_RS03980	797430..798596	-	1167	WP_024225550.1	restriction endonuclease	-
E9097_RS03985	798692..798901	+	210	WP_001534843.1	BrnT family toxin	Toxin
E9097_RS03990	798898..799200	+	303	WP_000063161.1	BrnA antitoxin family protein	Antitoxin
E9097_RS03995	799234..800190	-	957	WP_001314406.1	GTPase	-
E9097_RS04000	800201..800404	-	204	WP_000467859.1	YbdD/YjiX family protein	-
E9097_RS04005	800522..802672	-	2151	WP_032343687.1	pyruvate/proton symporter BtsT	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (37-93)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7952.17 Da
• Isoelectric Point: 4.9493

>T123906 WP_001534843.1 NZ_CP039404:798692-798901 [Escherichia coli]
MVDYPKRDAISNINAIIVDTFLYIQLGMATMPMEFEWNANKAKSNRVKHGIRFEDAVLVLDDPQRTEPL

Nucleotide

• Length: 210 bp

>T123906 NZ_CP039404:798692-798901 [Escherichia coli]
ATGGTTGATTATCCAAAACGTGATGCTATTTCCAACATCAACGCTATAATTGTAGATACATTTTTGTATATACAATTAGG
GATGGCAACTATGCCAATGGAGTTTGAATGGAATGCAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTG
AAGATGCGGTGTTAGTGCTTGATGATCCACAACGAACGGAGCCGCTATGA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11600.10 Da
• Isoelectric Point: 9.4646

>AT123906 WP_000063161.1 NZ_CP039404:798898-799200 [Escherichia coli]
MSMVKHKRGTSSTLDVQHEAELKVLANKFDEDIDYSDIPSSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Nucleotide

• Length: 303 bp

>AT123906 NZ_CP039404:798898-799200 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGTGCTGGCGAA
CAAATTCGACGAGGATATTGATTACAGCGACATCCCATCTTCCAGCGATGAGCAATGGTCTAACGCAGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCTGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Structures

Antitoxin

• AlphaFold DB: A0A0V9L4L3