Detailed information of TA system TA123904

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 433262..434250
• Replicon: chromosome
• Accession: NZ_CP039404
• Organism: Escherichia coli strain 377323_2f

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: E9097_RS02105
• Protein ID: WP_014640052.1
• Coordinates: 433864..434250 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: A0A0A1AFM1
• Locus tag: E9097_RS02100
• Protein ID: WP_000458583.1
• Coordinates: 433262..433834 (+)
• Length: 191 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E9097_RS02075	429424..429792	+	369	WP_000002899.1	diacylglycerol kinase	-
E9097_RS02080	429902..430510	+	609	WP_000646078.1	transcriptional repressor LexA	-
E9097_RS02085	430583..431908	+	1326	WP_001296637.1	MATE family efflux transporter DinF	-
E9097_RS02090	432024..432233	+	210	WP_001296638.1	CsbD family protein	-
E9097_RS02095	432275..432790	-	516	WP_000416264.1	zinc uptake transcriptional repressor Zur	-
E9097_RS02100	433262..433834	+	573	WP_000458583.1	SocA family protein	Antitoxin
E9097_RS02105	433864..434250	+	387	WP_014640052.1	hypothetical protein	Toxin
E9097_RS25270	434290..434463	+	174	WP_021559700.1	hypothetical protein	-
E9097_RS02110	434511..434792	-	282	WP_001093916.1	pyocin activator PrtN family protein	-
E9097_RS02115	434829..435401	-	573	WP_021559699.1	3'-5' exoribonuclease	-
E9097_RS02120	435401..436153	-	753	WP_021559698.1	DUF551 domain-containing protein	-
E9097_RS02125	436156..436347	-	192	WP_001014291.1	hypothetical protein	-
E9097_RS25420	436349..436534	-	186	Protein_389	ead/Ea22-like family protein	-
E9097_RS25425	436646..436877	-	232	Protein_390	ead/Ea22-like family protein	-
E9097_RS02135	436874..437113	-	240	WP_000476214.1	hypothetical protein	-
E9097_RS02140	437106..437309	-	204	WP_000111289.1	hypothetical protein	-
E9097_RS02145	437306..437668	-	363	WP_021559696.1	phage protein	-
E9097_RS02150	437659..438195	-	537	WP_000008178.1	5'-deoxynucleotidase	-
E9097_RS02155	438324..439148	-	825	WP_000081295.1	YfdQ family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	429902..485500	55598

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (27-137)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14465.40 Da
• Isoelectric Point: 5.4833

>T123904 WP_014640052.1 NZ_CP039404:433864-434250 [Escherichia coli]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE

Nucleotide

• Length: 387 bp

>T123904 NZ_CP039404:433864-434250 [Escherichia coli]
GTGCTTGCCCCAACTGGGCCATGCAATCATCTTCATGTGATTTGTAATGATCCTGTTTATTACCCCGTTAACGATTGTTA
TTGTGTTTTAGTTGTTAATATTTCTAGTATCAAGGATGGTGTCCCCCACGATCCGTCTTGCGTCTTGAATTCTGGTGATC
ATCGCTTTATCAAGCATCCAAGTTATGTTGTTTACGCTGAAGCTATAATTTGGCGAGTGGATAACATGGTTAGAAAGCAG
CGATCGGGTGAGATTTCCGTTCATGATGATATGCCAGAAGCTACATTCAATAGAATTCTGGACGGTTTTGATATATCTGA
TGAAGTTACGCCAAAGAACCTTAAATTTAAAAATAAATATTGCGTATCATCTATTGATGATGAGTAA

Antitoxin

Protein

• Length: 191 a.a.
• Molecular weight: 21956.30 Da
• Isoelectric Point: 6.0283

>AT123904 WP_000458583.1 NZ_CP039404:433262-433834 [Escherichia coli]
MFCEEKVAQMAAYLLLKRGGRMAYLKLMKLLYLSNRKSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYN
LIETNGHDVLLRSDPREMDADEVFDELSRADIRILDEIYSLYGHMNRFDLANMTHLESVCPEWHNPGNSRKPIDLKEMLI
SEGKSEDEANRIIGKMEESQKLKEFSLQLS

Nucleotide

• Length: 573 bp

>AT123904 NZ_CP039404:433262-433834 [Escherichia coli]
ATGTTTTGCGAAGAAAAAGTAGCTCAAATGGCTGCATACCTACTTCTTAAGCGAGGTGGGCGCATGGCATATCTGAAATT
GATGAAGCTGCTCTATCTGTCTAACCGCAAGTCGATTTTGAAGCATGGCAGGATGATCGGCGAAGATAGCCTTTACTCTA
TGAAATTTGGTCCAGTCATGTCGAATACGCTGAACTTGATTCGTGGTAAGGCTGAAGGTATTGGTGACTACTGGTACAAC
CTGATAGAGACGAACGGGCATGATGTGTTGTTGCGTTCAGATCCGAGGGAAATGGATGCAGACGAGGTCTTTGATGAGTT
GAGCCGTGCAGATATCCGGATTTTAGATGAAATCTATTCTCTGTATGGGCATATGAACCGATTTGATCTCGCAAACATGA
CGCATTTAGAAAGCGTTTGTCCAGAGTGGCACAATCCTGGCAATTCTCGTAAGCCTATAGACCTGAAAGAAATGCTGATC
AGTGAGGGTAAAAGCGAGGATGAGGCTAATCGTATAATTGGCAAAATGGAAGAATCTCAGAAACTTAAGGAATTTTCTTT
GCAATTATCATGA

Structures

Antitoxin

• AlphaFold DB: A0A0A1AFM1