Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 44606..45140 Replicon plasmid unnamed4
Accession NZ_CP039392
Organism Enterobacter hormaechei strain cre64

Toxin (Protein)


Gene name relE Uniprot ID A0A6P1V8P2
Locus tag EZJ11_RS26945 Protein ID WP_000143805.1
Coordinates 44606..44896 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7I6XZR7
Locus tag EZJ11_RS26950 Protein ID WP_000104338.1
Coordinates 44886..45140 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EZJ11_RS26925 (EZJ11_27280) 40004..40570 - 567 WP_003159185.1 recombinase family protein -
EZJ11_RS26930 (EZJ11_27285) 40699..40947 - 249 WP_011191340.1 type II toxin-antitoxin system YafQ family toxin -
EZJ11_RS26935 (EZJ11_27300) 41765..42469 - 705 WP_001067855.1 IS6-like element IS26 family transposase -
EZJ11_RS26940 (EZJ11_27305) 42541..44334 + 1794 Protein_50 Tn3-like element Tn5403 family transposase -
EZJ11_RS26945 (EZJ11_27310) 44606..44896 - 291 WP_000143805.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EZJ11_RS26950 (EZJ11_27315) 44886..45140 - 255 WP_000104338.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
EZJ11_RS26955 (EZJ11_27320) 45297..46007 - 711 WP_025760373.1 tyrosine-type recombinase/integrase -
EZJ11_RS26960 (EZJ11_27325) 46094..46627 - 534 WP_224019189.1 hypothetical protein -
EZJ11_RS26965 (EZJ11_27330) 47257..49086 + 1830 WP_025760371.1 hypothetical protein -
EZJ11_RS26970 (EZJ11_27335) 49336..49785 + 450 WP_045911952.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid mph(A) / sul1 / qacE / ARR-3 / catB3 / blaOXA-1 / aac(6')-Ib-cr mrkA / mrkB / mrkC / mrkD / mrkF / mrkA / mrkB / mrkC / mrkD / mrkF 1..118167 118167


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-47)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11463.41 Da        Isoelectric Point: 10.2689

>T123876 WP_000143805.1 NZ_CP039392:c44896-44606 [Enterobacter hormaechei]
MTFNVEFDERAFKEWNKLEKTIREQFKKKLKKLQQNPYVESARLHGDLAGCFKIKLRASGFRLIYKVIDDEIVIWVVAVG
KREDEKAYETARKRLL

Download         Length: 291 bp

>T123876 NZ_CP039392:c44896-44606 [Enterobacter hormaechei]
ATGACCTTTAATGTTGAATTTGACGAAAGGGCGTTTAAGGAATGGAATAAGCTCGAAAAGACGATCCGTGAGCAATTCAA
AAAGAAGCTAAAAAAGCTTCAGCAAAACCCTTATGTGGAATCAGCCCGACTGCATGGTGATCTGGCTGGCTGCTTTAAAA
TAAAGCTGAGAGCATCTGGTTTTCGTTTGATTTACAAGGTTATCGATGACGAGATTGTTATATGGGTGGTCGCAGTAGGT
AAACGGGAAGACGAAAAAGCCTATGAAACGGCCCGAAAGCGTCTTTTATAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9708.04 Da        Isoelectric Point: 4.4247

>AT123876 WP_000104338.1 NZ_CP039392:c45140-44886 [Enterobacter hormaechei]
MSTIQIRVDDELKKDAYQAFEKLNLSPSDALRLFLRYVAENEKLPFAEVSVMVSEDDEDADILAVVRERLKNPARRIRVN
VDDL

Download         Length: 255 bp

>AT123876 NZ_CP039392:c45140-44886 [Enterobacter hormaechei]
ATGAGCACAATTCAAATCCGCGTTGATGACGAACTGAAAAAAGACGCCTATCAGGCCTTTGAAAAACTGAATCTGTCGCC
TTCGGACGCACTTCGTCTGTTCCTGCGGTATGTTGCAGAGAACGAAAAACTCCCCTTTGCTGAAGTCTCAGTGATGGTGA
GCGAAGATGATGAAGACGCTGATATTCTGGCAGTTGTTCGGGAAAGACTGAAAAATCCGGCAAGACGGATCAGGGTTAAC
GTTGATGACCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6P1V8P2

Antitoxin

Source ID Structure
AlphaFold DB A0A7I6XZR7

References