Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 320408..320934 | Replicon | plasmid unnamed2 |
| Accession | NZ_CP039390 | ||
| Organism | Enterobacter hormaechei strain cre64 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | EZJ11_RS25935 | Protein ID | WP_000323025.1 |
| Coordinates | 320647..320934 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | EZJ11_RS25930 | Protein ID | WP_000534858.1 |
| Coordinates | 320408..320647 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EZJ11_RS25910 (EZJ11_26230) | 316736..317974 | + | 1239 | WP_000219087.1 | IS110-like element ISEsa2 family transposase | - |
| EZJ11_RS25915 (EZJ11_26235) | 318450..319022 | + | 573 | WP_001515348.1 | cytochrome b/b6 domain-containing protein | - |
| EZJ11_RS25920 (EZJ11_26240) | 319222..320145 | + | 924 | WP_000167917.1 | cation diffusion facilitator family transporter | - |
| EZJ11_RS25925 | 320279..320383 | - | 105 | Protein_353 | protein YdfV | - |
| EZJ11_RS25930 (EZJ11_26250) | 320408..320647 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| EZJ11_RS25935 (EZJ11_26255) | 320647..320934 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| EZJ11_RS25940 (EZJ11_26260) | 321006..321164 | + | 159 | WP_001447866.1 | type I toxin-antitoxin system Hok family toxin | - |
| EZJ11_RS25945 (EZJ11_26265) | 321773..322093 | - | 321 | WP_000332796.1 | hypothetical protein | - |
| EZJ11_RS25950 (EZJ11_26270) | 322375..322578 | - | 204 | WP_001015183.1 | hypothetical protein | - |
| EZJ11_RS25955 (EZJ11_26275) | 322625..322975 | - | 351 | WP_000743059.1 | hypothetical protein | - |
| EZJ11_RS25960 (EZJ11_26280) | 323035..323637 | - | 603 | WP_012695474.1 | hypothetical protein | - |
| EZJ11_RS25965 (EZJ11_26285) | 323733..324677 | - | 945 | WP_000778029.1 | DUF5417 domain-containing protein | - |
| EZJ11_RS25970 | 325188..325364 | + | 177 | WP_001371930.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | aph(3')-Ia / mcr-9 / aph(6)-Id / aph(3'')-Ib / dfrA19 / blaTEM-1B / aac(6')-IIc / ere(A) / qacE / sul1 / qnrB4 / blaDHA-1 / blaSHV-12 / catA2 / tet(D) | - | 1..337017 | 337017 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T123875 WP_000323025.1 NZ_CP039390:320647-320934 [Enterobacter hormaechei]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T123875 NZ_CP039390:320647-320934 [Enterobacter hormaechei]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT123875 WP_000534858.1 NZ_CP039390:320408-320647 [Enterobacter hormaechei]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT123875 NZ_CP039390:320408-320647 [Enterobacter hormaechei]
ATGGGTAGCATTAACCTACGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGACTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTACGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGACTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|