Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4093561..4094300 Replicon chromosome
Accession NZ_CP039388
Organism Enterobacter hormaechei strain cre64

Toxin (Protein)


Gene name tacT Uniprot ID A0A822W909
Locus tag EZJ11_RS19825 Protein ID WP_017382345.1
Coordinates 4093561..4094046 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag EZJ11_RS19830 Protein ID WP_003857131.1
Coordinates 4094034..4094300 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EZJ11_RS19800 (EZJ11_20080) 4089048..4090016 - 969 WP_013815099.1 IS5-like element IS903B family transposase -
EZJ11_RS19805 (EZJ11_20085) 4090048..4090419 - 372 Protein_3865 IS5/IS1182 family transposase -
EZJ11_RS19810 (EZJ11_20090) 4090494..4091126 + 633 WP_001567369.1 hypothetical protein -
EZJ11_RS19815 (EZJ11_20095) 4091155..4092558 - 1404 WP_001567368.1 ISNCY-like element ISKpn21 family transposase -
EZJ11_RS19820 (EZJ11_20100) 4092941..4093510 + 570 WP_017382346.1 hypothetical protein -
EZJ11_RS19825 (EZJ11_20105) 4093561..4094046 - 486 WP_017382345.1 GNAT family N-acetyltransferase Toxin
EZJ11_RS19830 (EZJ11_20110) 4094034..4094300 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
EZJ11_RS19835 (EZJ11_20115) 4094364..4095293 - 930 WP_023303744.1 LysR family transcriptional regulator -
EZJ11_RS19840 (EZJ11_20120) 4095423..4096811 + 1389 WP_032619651.1 MFS transporter -
EZJ11_RS19845 (EZJ11_20125) 4096833..4097828 - 996 WP_023303746.1 DUF2891 domain-containing protein -
EZJ11_RS19850 (EZJ11_20130) 4097838..4098824 - 987 WP_017382341.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17510.21 Da        Isoelectric Point: 9.9658

>T123862 WP_017382345.1 NZ_CP039388:c4094046-4093561 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARAFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T123862 NZ_CP039388:c4094046-4093561 [Enterobacter hormaechei]
GTGGGACGTGTAACAGCACCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCGTCAGCGGAGAGGCCGTGCTTGA
CGAATGGCTAAAACAAAGAGGTCTGAAAAACCAGGCGCTCGGCGCAGCCCGAGCGTTTGTCGTTTGTAAAACGGGCACGA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGCAGCGTTAACCATACGCAAGCGACAGGTAATCTGCGGCGTAACATG
CCGGATCCCATTCCCGTGATTATACTTGCCCGTCTGGCTGTGGATGTCTCGTTACGCGGAAACGGGTTGGGAGCCGATTT
ACTCCACGATGCGGTTTTACGCTGTTATCGGGTAGCTGAGAATATCGGGGTGCGAGCGATCATGGTTCATGCACTCACTG
AGGAAGCCAAAGCGTTTTATATCCACCATGGTTTCAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCAGGCTTCCT
CAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT123862 WP_003857131.1 NZ_CP039388:c4094300-4094034 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT123862 NZ_CP039388:c4094300-4094034 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAACTCAATCTCAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGCACGGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAGAATGTGATCCTCGATCGACGTGTATTCAATT
TTAACGATGAACAGTACGCAGAGTTCATTGACATGCTCGATGCCCCGGTCGCGGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCGCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A822W909

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References