Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2809745..2810365 Replicon chromosome
Accession NZ_CP039388
Organism Enterobacter hormaechei strain cre64

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag EZJ11_RS13490 Protein ID WP_015571250.1
Coordinates 2809745..2809963 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag EZJ11_RS13495 Protein ID WP_006809850.1
Coordinates 2809991..2810365 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EZJ11_RS13460 (EZJ11_13655) 2805757..2806017 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
EZJ11_RS13465 (EZJ11_13660) 2806020..2806160 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
EZJ11_RS13470 (EZJ11_13665) 2806157..2806867 - 711 WP_023303201.1 GNAT family protein -
EZJ11_RS13475 (EZJ11_13670) 2806969..2808429 + 1461 WP_032620143.1 PLP-dependent aminotransferase family protein -
EZJ11_RS13480 (EZJ11_13675) 2808401..2808868 - 468 WP_017383209.1 YlaC family protein -
EZJ11_RS13485 (EZJ11_13680) 2808985..2809536 - 552 WP_023303203.1 maltose O-acetyltransferase -
EZJ11_RS13490 (EZJ11_13685) 2809745..2809963 - 219 WP_015571250.1 HHA domain-containing protein Toxin
EZJ11_RS13495 (EZJ11_13690) 2809991..2810365 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
EZJ11_RS13500 (EZJ11_13695) 2810876..2814022 - 3147 WP_015571248.1 multidrug efflux RND transporter permease subunit AcrB -
EZJ11_RS13505 (EZJ11_13700) 2814045..2815238 - 1194 WP_017694395.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T123861 WP_015571250.1 NZ_CP039388:c2809963-2809745 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T123861 NZ_CP039388:c2809963-2809745 [Enterobacter hormaechei]
ATGTCTGATAAACCATTAACAAAAGTCGATTATTTGATGCGCCTGCGACGCTGCCAGTCAATTGACACCCTTGAACGAGT
TATTGAGAAAAATAAATACGAGCTGTCTGATAATGAACTGGCGGTATTTTATTCAGCTGCCGACCATCGTCTTGCTGAGC
TGACCATGAATAAACTGTATGACAAGATCCCCTCTTCGGTGTGGAAATTTGTTCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT123861 WP_006809850.1 NZ_CP039388:c2810365-2809991 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT123861 NZ_CP039388:c2810365-2809991 [Enterobacter hormaechei]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGAAGAAAGTAACCATGGCTGGGTGAACGATCCAACGTCTGCTATCAATTTACAGCTTAACGAGCTGATCGAGC
ATATCGCCACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGTTGATAGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTACGGCATTAACGCACAGGATTTGCAGAAATGGCGTAAATCAGGAAACCGTCT
ATTTCGCTGCTTCACTAATGTCAGCAGAGCTAATCCGGTTAGTCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References