Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 667483..668140 Replicon chromosome
Accession NZ_CP039388
Organism Enterobacter hormaechei strain cre64

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag EZJ11_RS03130 Protein ID WP_017382887.1
Coordinates 667483..667893 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag EZJ11_RS03135 Protein ID WP_003863437.1
Coordinates 667874..668140 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EZJ11_RS03110 (EZJ11_03160) 663481..665214 - 1734 WP_023304383.1 single-stranded-DNA-specific exonuclease RecJ -
EZJ11_RS03115 (EZJ11_03165) 665220..665933 - 714 WP_023295380.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
EZJ11_RS03120 (EZJ11_03170) 665962..666858 - 897 WP_023304385.1 site-specific tyrosine recombinase XerD -
EZJ11_RS03125 (EZJ11_03175) 666960..667481 + 522 WP_015571793.1 flavodoxin FldB -
EZJ11_RS03130 (EZJ11_03180) 667483..667893 - 411 WP_017382887.1 protein YgfX Toxin
EZJ11_RS03135 (EZJ11_03185) 667874..668140 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
EZJ11_RS03140 (EZJ11_03190) 668435..669415 + 981 WP_022649306.1 tRNA-modifying protein YgfZ -
EZJ11_RS03145 (EZJ11_03195) 669527..670186 - 660 WP_003863433.1 hemolysin III family protein -
EZJ11_RS03150 (EZJ11_03200) 670453..671184 + 732 WP_015571796.1 MurR/RpiR family transcriptional regulator -
EZJ11_RS03155 (EZJ11_03205) 671301..672734 + 1434 WP_017382891.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T123858 WP_017382887.1 NZ_CP039388:c667893-667483 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T123858 NZ_CP039388:c667893-667483 [Enterobacter hormaechei]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGGCTGGTGGCGGC
ACTGGTGTTATTGGTGCCGTGGCCGCTTAGCTATACCCCTCTGTGGTTGCTATTGCTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAGATGATGGGGACGCCGTGGATGCTTAATACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGATAACCGTCG
CCAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCCGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT123858 WP_003863437.1 NZ_CP039388:c668140-667874 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT123858 NZ_CP039388:c668140-667874 [Enterobacter hormaechei]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References