Detailed information of TA system TA123851

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 3621452..3622269
• Replicon: chromosome
• Accession: NZ_CP039377
• Organism: Morganella morganii strain Jiangxi

Toxin (Protein)

• Gene name: TacT2
• Uniprot ID: -
• Locus tag: E7Y21_RS17195
• Protein ID: WP_015422406.1
• Coordinates: 3621452..3621958 (-)
• Length: 169 a.a.

Antitoxin (Protein)

• Gene name: TacA2
• Uniprot ID: J7TDK6
• Locus tag: E7Y21_RS17200
• Protein ID: WP_004236533.1
• Coordinates: 3621961..3622269 (-)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E7Y21_RS17165	3616816..3617439	-	624	WP_004236525.1	thiol:disulfide interchange protein DsbA	-
E7Y21_RS17170	3617458..3618453	-	996	WP_004236526.1	serine/threonine protein kinase	-
E7Y21_RS17175	3618453..3618722	-	270	WP_004240741.1	YihD family protein	-
E7Y21_RS17180	3618925..3620040	+	1116	WP_052697390.1	molybdenum cofactor guanylyltransferase MobA	-
E7Y21_RS17185	3620250..3620552	+	303	WP_004236529.1	ABC transporter substrate-binding protein	-
E7Y21_RS17190	3620680..3621201	+	522	WP_176877246.1	isopentenyl-diphosphate Delta-isomerase	-
E7Y21_RS17195	3621452..3621958	-	507	WP_015422406.1	GNAT family N-acetyltransferase	Toxin
E7Y21_RS17200	3621961..3622269	-	309	WP_004236533.1	DUF1778 domain-containing protein	Antitoxin
E7Y21_RS17205	3622401..3623753	-	1353	WP_004236534.1	glutathione-disulfide reductase	-
E7Y21_RS17210	3623823..3624665	-	843	WP_046024793.1	23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ	-
E7Y21_RS17215	3624855..3625244	+	390	WP_004236536.1	DUF1090 domain-containing protein	-
E7Y21_RS17220	3625656..3626648	+	993	WP_046024794.1	inner membrane protein YhjD	-
E7Y21_RS17225	3626756..3626962	+	207	WP_004236540.1	4-oxalocrotonate tautomerase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (44-143)

Antitoxin

• Vibrio phage ICP1, Orf50 (21-94)

Sequences

Toxin

Protein

• Length: 169 a.a.
• Molecular weight: 18565.43 Da
• Isoelectric Point: 9.9508

>T123851 WP_015422406.1 NZ_CP039377:c3621958-3621452 [Morganella morganii]
MNLTAPEPLQQHHDFTVFQSGEESLNHWLKTRALQNQQSGASRTFVVCHHNRIMAYYALSTGVITCSQAAGRFRRNMPPE
IPVILPGRLAVDESVKGRGIGRGLIKDAALRVLQAAGIVGIRGIVVRALSDNARRFYEHTGFMPSPADPMLLMITLRDLQ
LATGIYSE

Nucleotide

• Length: 507 bp

>T123851 NZ_CP039377:c3621958-3621452 [Morganella morganii]
TTGAACTTAACGGCACCGGAACCCTTGCAGCAGCATCATGATTTTACCGTTTTTCAGTCAGGTGAGGAGTCCCTTAACCA
TTGGCTGAAAACCCGCGCATTGCAAAATCAGCAATCCGGCGCTTCACGGACATTTGTCGTCTGCCACCATAACCGGATAA
TGGCCTATTATGCATTATCGACAGGTGTTATTACCTGTTCACAGGCGGCGGGACGCTTCAGACGTAATATGCCTCCGGAA
ATTCCGGTTATTCTGCCGGGACGTCTTGCTGTTGATGAAAGCGTAAAAGGCAGAGGGATCGGACGGGGTCTGATAAAAGA
TGCCGCACTGCGGGTCTTGCAGGCAGCCGGGATTGTGGGTATCCGCGGTATTGTTGTCCGTGCTCTGTCTGATAATGCCA
GACGTTTTTATGAGCATACCGGTTTTATGCCGTCACCGGCTGACCCGATGCTGCTGATGATTACATTACGGGATCTGCAG
CTGGCAACCGGTATCTATTCTGAATAG

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11499.15 Da
• Isoelectric Point: 8.6397

>AT123851 WP_004236533.1 NZ_CP039377:c3622269-3621961 [Morganella morganii]
MTKHTDEQHPVSGVNITRSTLNLRIKPEDKILIDRAAHAAGKNRTEFVLEAARRAAEETLADLRVIDVSTDVYQQFITRL
DMAPQSGEALKKTMLTKAPWEK

Nucleotide

• Length: 309 bp

>AT123851 NZ_CP039377:c3622269-3621961 [Morganella morganii]
ATGACAAAACACACAGATGAGCAGCATCCTGTGTCCGGCGTGAATATCACCCGTTCAACACTGAATTTACGCATCAAACC
GGAAGATAAAATTCTGATTGATCGCGCAGCGCATGCTGCCGGTAAAAACAGAACCGAGTTCGTACTGGAAGCTGCGCGGC
GTGCCGCCGAAGAAACACTGGCAGATTTACGGGTTATTGATGTCAGTACCGATGTCTATCAGCAGTTTATTACCAGACTG
GATATGGCACCACAGTCCGGTGAGGCGCTGAAGAAGACCATGCTGACGAAGGCGCCGTGGGAGAAGTAA

Structures

Antitoxin

• AlphaFold DB: J7TDK6