Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1287149..1287789 Replicon chromosome
Accession NZ_CP039374
Organism Halomonas titanicae strain ANRCS81

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag E8A47_RS05705 Protein ID WP_208797182.1
Coordinates 1287388..1287789 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag E8A47_RS05700 Protein ID WP_141439728.1
Coordinates 1287149..1287379 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E8A47_RS05680 1282736..1283860 - 1125 WP_141439731.1 alanine--glyoxylate aminotransferase family protein -
E8A47_RS05685 1284133..1284912 + 780 WP_138799909.1 ThuA domain-containing protein -
E8A47_RS05690 1284909..1285958 + 1050 WP_141439730.1 Gfo/Idh/MocA family oxidoreductase -
E8A47_RS05695 1286033..1287034 + 1002 WP_141439729.1 LacI family transcriptional regulator -
E8A47_RS05700 1287149..1287379 + 231 WP_141439728.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
E8A47_RS05705 1287388..1287789 + 402 WP_208797182.1 PIN domain-containing protein Toxin
E8A47_RS05710 1288094..1288588 + 495 WP_208797151.1 thioesterase family protein -
E8A47_RS05715 1288618..1289037 - 420 WP_141439725.1 cytidine deaminase -
E8A47_RS05720 1289050..1289775 - 726 WP_141439724.1 purine-nucleoside phosphorylase -
E8A47_RS05725 1289805..1291049 - 1245 WP_141439723.1 phosphopentomutase -
E8A47_RS05730 1291046..1292401 - 1356 WP_141439722.1 thymidine phosphorylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

SpoVT-AbrB domain

(7-53)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14514.73 Da        Isoelectric Point: 7.7772

>T123847 WP_208797182.1 NZ_CP039374:1287388-1287789 [Halomonas titanicae]
MLDTCICSFIMREQAASVISRLATEVGQGNRIVVSTVTYAEMRYGQIGKKASAKHKSLVDEFVKRLDAVLPWDKQAVDAT
VEIMRVLAKAGTPIGSNDSAIAGHAMASTCTLVTNNVREFSRVPGLVYEDWVH

Download         Length: 402 bp

>T123847 NZ_CP039374:1287388-1287789 [Halomonas titanicae]
ATGCTGGATACCTGTATCTGTTCATTCATTATGCGCGAACAAGCAGCATCGGTTATCAGTCGCCTAGCCACTGAGGTTGG
GCAGGGGAATCGAATAGTTGTATCGACGGTTACCTATGCAGAAATGCGCTATGGTCAAATCGGCAAGAAAGCATCTGCTA
AGCACAAGTCTCTTGTTGATGAATTCGTGAAGCGATTGGATGCTGTATTGCCCTGGGATAAGCAAGCCGTGGATGCAACC
GTTGAGATAATGCGGGTGTTAGCTAAAGCAGGCACGCCTATTGGCTCAAACGACTCGGCCATTGCAGGGCATGCAATGGC
CTCGACTTGCACCCTGGTTACCAACAACGTGCGTGAATTTAGCCGTGTTCCAGGGTTGGTTTATGAAGATTGGGTGCATT
AA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8651.77 Da        Isoelectric Point: 4.4230

>AT123847 WP_141439728.1 NZ_CP039374:1287149-1287379 [Halomonas titanicae]
MRTVSIFKNGKNQAVRLPNDMAYEGIGELEITREGDVITLRPVRPSWVSFSELPKADDDFLIERPNVVSDEGRFDL

Download         Length: 231 bp

>AT123847 NZ_CP039374:1287149-1287379 [Halomonas titanicae]
ATGCGTACAGTATCCATTTTCAAAAACGGCAAAAATCAAGCCGTCCGGTTACCTAACGATATGGCATATGAGGGTATCGG
AGAGCTTGAAATCACGCGTGAAGGCGACGTCATCACATTGCGGCCTGTACGCCCCTCGTGGGTATCCTTCTCTGAACTAC
CCAAAGCGGATGACGATTTTCTAATTGAGCGTCCTAACGTTGTGAGTGATGAGGGCAGGTTCGATCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References