Detailed information of TA system TA123843

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 327874..328514
• Replicon: chromosome
• Accession: NZ_CP039374
• Organism: Halomonas titanicae strain ANRCS81

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: E8A47_RS01535
• Protein ID: WP_084625441.1
• Coordinates: 328332..328514 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: E8A47_RS01530
• Protein ID: WP_141440133.1
• Coordinates: 327874..328293 (-)
• Length: 140 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E8A47_RS01490	323109..323498	-	390	WP_161575186.1	acyl carrier protein	-
E8A47_RS01495	323398..323634	-	237	Protein_286	acyl carrier protein	-
E8A47_RS01500	323606..324394	-	789	WP_141440134.1	1-acyl-sn-glycerol-3-phosphate acyltransferase	-
E8A47_RS01505	324391..325059	-	669	WP_201764700.1	beta-ketoacyl synthase chain length factor	-
E8A47_RS01510	325114..325281	+	168	WP_083868831.1	hypothetical protein	-
E8A47_RS01515	325303..326085	+	783	WP_009287879.1	sulfite exporter TauE/SafE family protein	-
E8A47_RS01520	326096..327280	-	1185	WP_141441476.1	MFS transporter	-
E8A47_RS01525	327399..327578	-	180	WP_208797109.1	hypothetical protein	-
E8A47_RS01530	327874..328293	-	420	WP_141440133.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
E8A47_RS01535	328332..328514	-	183	WP_084625441.1	type II toxin-antitoxin system HicA family toxin	Toxin
E8A47_RS01540	328844..329179	-	336	WP_141440132.1	type II toxin-antitoxin system HicB family antitoxin	-
E8A47_RS24385	329176..329433	-	258	WP_208797111.1	type II toxin-antitoxin system HicA family toxin	-
E8A47_RS01555	329731..331128	+	1398	WP_141440131.1	site-specific integrase	-
E8A47_RS01560	331469..332164	+	696	WP_141440130.1	hypothetical protein	-
E8A47_RS01565	332462..332893	-	432	WP_141440129.1	DUF559 domain-containing protein	-
E8A47_RS01570	333240..333389	+	150	WP_161575187.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6756.92 Da
• Isoelectric Point: 11.4650

>T123843 WP_084625441.1 NZ_CP039374:c328514-328332 [Halomonas titanicae]
VDSRTLIKELKKDGWELVRVNGSHHHFRHPTKPGTVTVPHPKKDLKTGLVRAIRKSAGLL

Nucleotide

• Length: 183 bp

>T123843 NZ_CP039374:c328514-328332 [Halomonas titanicae]
GTGGATAGCAGAACACTGATAAAAGAACTGAAGAAAGATGGCTGGGAGTTGGTCAGAGTCAACGGCAGCCACCACCACTT
CAGGCACCCTACCAAGCCCGGCACGGTCACCGTGCCACATCCTAAAAAGGATTTGAAAACGGGCTTGGTAAGAGCAATCA
GAAAAAGCGCCGGTCTCTTATGA

Antitoxin

Protein

• Length: 140 a.a.
• Molecular weight: 15162.13 Da
• Isoelectric Point: 4.4217

>AT123843 WP_141440133.1 NZ_CP039374:c328293-327874 [Halomonas titanicae]
MLFPIAIERGDEQHAYGVVVPDLNGCFSAGDTFEEALANVKAAIEGWLEVAVDYGDPIPEATSIEHHMDNPDYAGWIWAV
VDIDLTPYLGKSHKINVTLPDLLVKQIDDFVASHPGDKTRSGFLSRVAMAELARARKGA

Nucleotide

• Length: 420 bp

>AT123843 NZ_CP039374:c328293-327874 [Halomonas titanicae]
ATGTTGTTTCCCATTGCAATTGAGCGCGGCGACGAACAGCACGCCTATGGCGTCGTAGTACCCGATCTTAACGGCTGCTT
TTCAGCGGGTGACACCTTTGAAGAGGCGTTAGCCAATGTGAAAGCAGCGATCGAAGGATGGCTGGAAGTAGCCGTGGACT
ATGGCGACCCCATTCCCGAAGCGACGTCCATTGAGCACCACATGGACAACCCTGATTACGCTGGTTGGATCTGGGCGGTG
GTCGATATAGACCTGACCCCCTACCTGGGCAAAAGCCACAAAATCAACGTCACATTACCTGATTTACTGGTTAAGCAAAT
TGACGACTTTGTGGCCAGCCACCCCGGCGACAAAACCCGCTCGGGCTTTCTCTCCCGCGTCGCCATGGCCGAACTGGCCA
GAGCACGCAAAGGCGCATAA