123840

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1629843..1630510 Replicon chromosome
Accession NZ_CP039373
Organism Synechococcus sp. CB0101

Toxin (Protein)


Gene name VapC1 Uniprot ID A0A4P7ZUS1
Locus tag CB0101_RS08720 Protein ID WP_010312521.1
Coordinates 1630097..1630510 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID A0A4P7ZU35
Locus tag CB0101_RS08715 Protein ID WP_043718332.1
Coordinates 1629843..1630100 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CB0101_RS08690 (CB0101_08675) 1627107..1627295 + 189 WP_010312528.1 photosystem II reaction center protein PsbZ -
CB0101_RS08695 (CB0101_08680) 1627318..1627797 + 480 WP_010312527.1 6,7-dimethyl-8-ribityllumazine synthase -
CB0101_RS08700 (CB0101_08685) 1627799..1628179 - 381 WP_029553194.1 clan AA aspartic protease -
CB0101_RS08705 (CB0101_08690) 1628290..1629186 + 897 WP_010312524.1 glucose-1-phosphate thymidylyltransferase RfbA -
CB0101_RS08710 (CB0101_08695) 1629186..1629803 + 618 WP_010312523.1 dTDP-4-dehydrorhamnose 3,5-epimerase -
CB0101_RS08715 (CB0101_08700) 1629843..1630100 + 258 WP_043718332.1 antitoxin Antitoxin
CB0101_RS08720 (CB0101_08705) 1630097..1630510 + 414 WP_010312521.1 type II toxin-antitoxin system VapC family toxin Toxin
CB0101_RS08725 (CB0101_08710) 1630507..1631406 + 900 WP_010312520.1 dTDP-4-dehydrorhamnose reductase -
CB0101_RS08730 (CB0101_08715) 1631393..1632712 + 1320 WP_010312519.1 sugar transferase -
CB0101_RS08735 (CB0101_08720) 1632721..1634058 - 1338 WP_168187968.1 phospholipid carrier-dependent glycosyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-126)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15390.61 Da        Isoelectric Point: 5.5729

>T123840 WP_010312521.1 NZ_CP039373:1630097-1630510 [Synechococcus sp. CB0101]
VIYLLDTNILIYLIKQRPPEVAERIDQLPGTAQLAMSFITWAELLQGAVGSSRRDAVERQLDHLARQVEVLYPEDSQICR
HYAEQATALRRAGTPIGANDLWIACHALAVDATLVTHNLREFTRMSGLSVVDWVQQP

Download         Length: 414 bp

>T123840 NZ_CP039373:1630097-1630510 [Synechococcus sp. CB0101]
GTGATCTATCTGCTCGACACCAACATCCTGATTTATCTGATCAAACAGCGTCCTCCCGAGGTGGCGGAGCGGATCGATCA
ACTGCCCGGCACCGCCCAGTTGGCGATGTCGTTCATCACCTGGGCGGAATTGCTGCAGGGGGCTGTGGGTAGCTCCAGGC
GGGATGCTGTGGAACGACAGCTCGATCACTTAGCTCGCCAGGTGGAGGTGCTGTATCCCGAGGATTCCCAGATCTGCCGC
CATTACGCCGAGCAGGCCACGGCGTTGCGTCGGGCTGGAACGCCGATCGGCGCCAACGATCTGTGGATCGCCTGCCATGC
CCTTGCCGTGGACGCCACCCTGGTTACGCATAACCTGCGCGAATTCACGCGCATGAGCGGGCTGTCTGTGGTGGATTGGG
TGCAGCAACCATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9319.42 Da        Isoelectric Point: 4.9859

>AT123840 WP_043718332.1 NZ_CP039373:1629843-1630100 [Synechococcus sp. CB0101]
MTASLPSRVFNNGNSQAVRIPAEFRLGTDQVQISRTPEGDLLIHPCPPQRGQALFNALAGFDADFAERLEQSRAEAQPIQ
TREGL

Download         Length: 258 bp

>AT123840 NZ_CP039373:1629843-1630100 [Synechococcus sp. CB0101]
ATGACAGCGTCATTGCCTAGCCGTGTGTTCAACAACGGCAATAGCCAGGCGGTTCGGATCCCGGCGGAGTTTCGGCTGGG
CACGGATCAGGTGCAGATCTCTCGCACGCCAGAGGGCGATCTGCTGATCCATCCTTGTCCGCCGCAGCGTGGTCAGGCGC
TGTTCAATGCGCTCGCTGGTTTCGACGCCGATTTCGCTGAACGTTTGGAGCAATCCCGTGCGGAGGCTCAGCCGATCCAG
ACCCGTGAGGGGTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7ZUS1

Antitoxin

Source ID Structure
AlphaFold DB A0A4P7ZU35

References