Detailed information of TA system TA123839

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /BrnT(toxin)
• Location: 1327498..1328005
• Replicon: chromosome
• Accession: NZ_CP039373
• Organism: Synechococcus sp. CB0101

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A4P7ZUQ6
• Locus tag: CB0101_RS07205
• Protein ID: WP_010311145.1
• Coordinates: 1327498..1327761 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A4P7ZUR7
• Locus tag: CB0101_RS07210
• Protein ID: WP_010311146.1
• Coordinates: 1327748..1328005 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CB0101_RS07175 (CB0101_07160)	1322591..1323017	+	427	Protein_1458	Zeta toxin family protein	-
CB0101_RS07180 (CB0101_07165)	1323014..1323232	+	219	WP_010311131.1	hypothetical protein	-
CB0101_RS07185 (CB0101_07170)	1323295..1323678	+	384	WP_010311133.1	nucleotidyltransferase domain-containing protein	-
CB0101_RS07190 (CB0101_07175)	1323632..1324048	+	417	WP_029553106.1	HEPN domain-containing protein	-
CB0101_RS07195 (CB0101_07180)	1324045..1326390	+	2346	WP_010311139.1	type I restriction endonuclease subunit R	-
CB0101_RS07200 (CB0101_07185)	1326387..1327303	-	917	Protein_1463	DUF1738 domain-containing protein	-
CB0101_RS07205 (CB0101_07190)	1327498..1327761	+	264	WP_010311145.1	BrnT family toxin	Toxin
CB0101_RS07210 (CB0101_07195)	1327748..1328005	+	258	WP_010311146.1	hypothetical protein	Antitoxin
CB0101_RS07215 (CB0101_07200)	1328037..1328222	-	186	WP_043718058.1	hypothetical protein	-
CB0101_RS07220 (CB0101_07205)	1328325..1329776	+	1452	WP_010311150.1	hypothetical protein	-
CB0101_RS15545 (CB0101_07210)	1329804..1330349	-	546	WP_029553107.1	DUF4351 domain-containing protein	-
CB0101_RS07235 (CB0101_07220)	1330477..1330662	-	186	WP_168187961.1	DUF2887 domain-containing protein	-
CB0101_RS07240 (CB0101_07225)	1331129..1331562	+	434	Protein_1470	nucleoside deaminase	-
CB0101_RS07245 (CB0101_07230)	1331662..1332741	-	1080	WP_136644032.1	photosystem II q(b) protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (5-80)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10183.63 Da
• Isoelectric Point: 6.4693

>T123839 WP_010311145.1 NZ_CP039373:1327498-1327761 [Synechococcus sp. CB0101]
MEFEFDPSKSQSNQEKHGIDFVAAQALWEDPALLEIAARTLDEPRWLVIGRIQRKHWSAVITLRGQAIRLISVRRSRPEE
IQLYEQL

Nucleotide

• Length: 264 bp

>T123839 NZ_CP039373:1327498-1327761 [Synechococcus sp. CB0101]
ATGGAGTTTGAGTTCGACCCGAGCAAAAGCCAGTCCAACCAGGAGAAGCACGGCATTGACTTCGTTGCCGCGCAGGCGCT
CTGGGAAGACCCCGCTTTGCTGGAGATCGCCGCGCGCACGCTGGATGAGCCGCGATGGCTCGTCATCGGTCGCATTCAGC
GCAAACACTGGTCAGCGGTGATCACCCTGCGCGGCCAAGCCATCCGACTCATCTCCGTCCGTCGATCACGCCCTGAGGAG
ATTCAGCTCTATGAACAGCTCTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9738.94 Da
• Isoelectric Point: 6.3062

>AT123839 WP_010311146.1 NZ_CP039373:1327748-1328005 [Synechococcus sp. CB0101]
MNSSEFDQSFDQGDSVLNSLDLASARRPRLQQKRVNVDFPLWMVEQLDREASRLGVTRQSIIKVWLSERLEPPLAADRPQ
ATGNR

Nucleotide

• Length: 258 bp

>AT123839 NZ_CP039373:1327748-1328005 [Synechococcus sp. CB0101]
ATGAACAGCTCTGAGTTTGATCAATCCTTCGATCAGGGCGATTCCGTGCTGAACTCGCTGGATCTCGCCTCCGCCCGGCG
GCCCCGTCTGCAGCAGAAGCGCGTCAATGTCGACTTTCCGCTCTGGATGGTCGAACAACTGGATCGGGAAGCGTCGCGCC
TCGGCGTGACGCGCCAGTCGATCATCAAGGTTTGGCTGTCGGAGCGGTTGGAGCCGCCTCTCGCGGCCGATCGGCCGCAG
GCCACCGGAAACCGCTGA

Structures

Toxin

• AlphaFold DB: A0A4P7ZUQ6

Antitoxin

• AlphaFold DB: A0A4P7ZUR7