Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 1149744..1150252 Replicon chromosome
Accession NZ_CP039373
Organism Synechococcus sp. CB0101

Toxin (Protein)


Gene name relE Uniprot ID A0A4P7ZTQ2
Locus tag CB0101_RS06250 Protein ID WP_010310651.1
Coordinates 1149983..1150252 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A4P7ZSZ2
Locus tag CB0101_RS06245 Protein ID WP_010310649.1
Coordinates 1149744..1149986 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CB0101_RS06230 (CB0101_06215) 1145853..1146896 + 1044 WP_010310639.1 AI-2E family transporter -
CB0101_RS06235 (CB0101_06220) 1146902..1147153 + 252 WP_010310641.1 hypothetical protein -
CB0101_RS06240 (CB0101_06225) 1147181..1149691 + 2511 WP_010310648.1 hypothetical protein -
CB0101_RS06245 (CB0101_06230) 1149744..1149986 + 243 WP_010310649.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CB0101_RS06250 (CB0101_06235) 1149983..1150252 + 270 WP_010310651.1 Txe/YoeB family addiction module toxin Toxin
CB0101_RS06255 (CB0101_06240) 1150294..1150818 + 525 WP_010310652.1 DUF3122 domain-containing protein -
CB0101_RS06260 (CB0101_06245) 1150839..1151894 + 1056 WP_168187997.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -
CB0101_RS06265 (CB0101_06250) 1151891..1152568 - 678 WP_050778804.1 potassium channel family protein -
CB0101_RS06270 (CB0101_06255) 1152674..1153321 - 648 WP_010310658.1 SOS response-associated peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10183.75 Da        Isoelectric Point: 10.5257

>T123838 WP_010310651.1 NZ_CP039373:1149983-1150252 [Synechococcus sp. CB0101]
VSWRVLFTRQAQKDARKLASSSPALKNKAQQLLELLAVDPFQQPPPFEALVGDLQGAYSRRINIQHRLVYAVDREAAVVK
VLRLWSHYD

Download         Length: 270 bp

>T123838 NZ_CP039373:1149983-1150252 [Synechococcus sp. CB0101]
GTGAGCTGGCGCGTTCTGTTCACCCGCCAGGCGCAGAAAGACGCGCGCAAGCTCGCTAGCTCCTCACCCGCTCTGAAGAA
CAAAGCCCAGCAATTGTTGGAGCTCCTGGCCGTCGATCCGTTCCAGCAACCACCACCATTCGAGGCCCTAGTGGGCGACT
TGCAGGGCGCTTACTCCCGGCGCATCAACATTCAGCACCGGCTGGTCTACGCAGTCGATCGTGAGGCCGCTGTGGTGAAG
GTGCTCAGGCTCTGGAGCCACTACGACTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8891.07 Da        Isoelectric Point: 4.4737

>AT123838 WP_010310649.1 NZ_CP039373:1149744-1149986 [Synechococcus sp. CB0101]
MGSISASEARRRLFALIDEVRESHQPVEIHGKRGSAVLLAEQDWRAIQETLYLCAIPGMRESILEGLATPVEELSEDAGW

Download         Length: 243 bp

>AT123838 NZ_CP039373:1149744-1149986 [Synechococcus sp. CB0101]
ATGGGCTCGATCAGTGCCAGCGAAGCCCGTCGGCGCTTATTTGCGTTGATCGACGAGGTGCGCGAATCGCACCAGCCCGT
TGAGATTCACGGCAAGCGCGGCAGCGCCGTCTTGCTCGCCGAGCAGGACTGGCGCGCGATTCAAGAGACCCTGTATCTGT
GCGCGATTCCCGGCATGCGGGAGTCGATCCTCGAGGGTCTTGCTACCCCTGTGGAGGAACTGAGCGAGGACGCCGGCTGG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7ZTQ2

Antitoxin

Source ID Structure
AlphaFold DB A0A4P7ZSZ2

References