Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC(toxin) |
| Location | 969840..970468 | Replicon | chromosome |
| Accession | NZ_CP039373 | ||
| Organism | Synechococcus sp. CB0101 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | A0A4P7ZRY2 |
| Locus tag | CB0101_RS05275 | Protein ID | WP_010306355.1 |
| Coordinates | 969840..970238 (-) | Length | 133 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | A0A4P7ZT40 |
| Locus tag | CB0101_RS05280 | Protein ID | WP_010306351.1 |
| Coordinates | 970238..970468 (-) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CB0101_RS05240 (CB0101_05225) | 965439..965540 | + | 102 | WP_071778115.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | - |
| CB0101_RS05245 (CB0101_05230) | 965578..965985 | - | 408 | WP_010306380.1 | type II toxin-antitoxin system VapC family toxin | - |
| CB0101_RS05250 (CB0101_05235) | 965985..966254 | - | 270 | WP_010306377.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| CB0101_RS05255 (CB0101_05240) | 966283..966810 | - | 528 | WP_136644243.1 | YdcF family protein | - |
| CB0101_RS05260 (CB0101_05245) | 967012..967242 | + | 231 | WP_010306369.1 | NUDIX domain-containing protein | - |
| CB0101_RS05265 (CB0101_05250) | 967430..968689 | - | 1260 | WP_043717254.1 | glycosyltransferase WbuB | - |
| CB0101_RS05270 (CB0101_05255) | 968780..969721 | - | 942 | WP_136643988.1 | hypothetical protein | - |
| CB0101_RS05275 (CB0101_05260) | 969840..970238 | - | 399 | WP_010306355.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| CB0101_RS05280 (CB0101_05265) | 970238..970468 | - | 231 | WP_010306351.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| CB0101_RS05285 (CB0101_05270) | 970558..971280 | - | 723 | WP_083798534.1 | YdcF family protein | - |
| CB0101_RS05290 (CB0101_05275) | 971270..972592 | - | 1323 | WP_136644244.1 | undecaprenyl-phosphate glucose phosphotransferase | - |
| CB0101_RS15530 | 972969..973160 | + | 192 | WP_010306342.1 | hypothetical protein | - |
| CB0101_RS15535 | 973171..973269 | + | 99 | WP_210409966.1 | helix-turn-helix domain-containing protein | - |
| CB0101_RS15540 | 973279..973429 | + | 151 | Protein_1076 | IS630 family transposase | - |
| CB0101_RS15290 | 973636..974010 | - | 375 | WP_168187916.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 133 a.a. Molecular weight: 14339.25 Da Isoelectric Point: 5.4970
>T123837 WP_010306355.1 NZ_CP039373:c970238-969840 [Synechococcus sp. CB0101]
MVIDPSAVLAILQNEPERQAFNAAIASADHCALSAALLVELSIVIEARYGSDGQGDLDLFLNTAQISIVSLDRGQAEIAR
AAFARYGKGRHRASLNLGDCFSYARAQWLEQPLLFKGHDFCHTDLQPACHVT
MVIDPSAVLAILQNEPERQAFNAAIASADHCALSAALLVELSIVIEARYGSDGQGDLDLFLNTAQISIVSLDRGQAEIAR
AAFARYGKGRHRASLNLGDCFSYARAQWLEQPLLFKGHDFCHTDLQPACHVT
Download Length: 399 bp
>T123837 NZ_CP039373:c970238-969840 [Synechococcus sp. CB0101]
ATGGTGATCGATCCCTCAGCCGTTCTGGCCATCCTTCAGAACGAACCGGAGCGTCAAGCCTTCAATGCAGCCATTGCCAG
TGCCGATCACTGCGCCTTGTCGGCCGCATTACTTGTAGAACTCTCGATCGTGATCGAGGCCCGGTACGGGTCTGATGGCC
AGGGAGATCTGGATCTGTTTCTCAACACGGCACAGATCAGCATCGTGAGCCTGGATCGCGGACAGGCCGAAATCGCACGC
GCAGCCTTCGCTCGGTACGGCAAGGGTCGTCATCGCGCCAGCCTCAATCTTGGCGATTGCTTCTCTTATGCCCGTGCCCA
GTGGCTCGAACAACCCCTGCTGTTCAAAGGTCATGATTTTTGCCACACCGATCTCCAGCCAGCCTGCCATGTGACATGA
ATGGTGATCGATCCCTCAGCCGTTCTGGCCATCCTTCAGAACGAACCGGAGCGTCAAGCCTTCAATGCAGCCATTGCCAG
TGCCGATCACTGCGCCTTGTCGGCCGCATTACTTGTAGAACTCTCGATCGTGATCGAGGCCCGGTACGGGTCTGATGGCC
AGGGAGATCTGGATCTGTTTCTCAACACGGCACAGATCAGCATCGTGAGCCTGGATCGCGGACAGGCCGAAATCGCACGC
GCAGCCTTCGCTCGGTACGGCAAGGGTCGTCATCGCGCCAGCCTCAATCTTGGCGATTGCTTCTCTTATGCCCGTGCCCA
GTGGCTCGAACAACCCCTGCTGTTCAAAGGTCATGATTTTTGCCACACCGATCTCCAGCCAGCCTGCCATGTGACATGA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8236.52 Da Isoelectric Point: 6.2033
>AT123837 WP_010306351.1 NZ_CP039373:c970468-970238 [Synechococcus sp. CB0101]
VALNIRNPEADRLAAQVACLAGETKSDAVILALKERLQRSLIYRLDQIALRCAARPILDLRSADEICGYDASGLPS
VALNIRNPEADRLAAQVACLAGETKSDAVILALKERLQRSLIYRLDQIALRCAARPILDLRSADEICGYDASGLPS
Download Length: 231 bp
>AT123837 NZ_CP039373:c970468-970238 [Synechococcus sp. CB0101]
GTGGCTCTCAACATCCGAAACCCGGAGGCAGATCGCCTGGCCGCACAGGTGGCCTGCCTCGCTGGCGAAACCAAATCGGA
TGCTGTGATCCTGGCCCTCAAGGAACGCCTCCAGCGTTCGCTGATCTATCGCCTCGATCAGATTGCCCTGCGCTGTGCGG
CTCGACCGATCCTGGATCTCCGCAGCGCTGACGAGATCTGCGGCTACGACGCCAGCGGCCTTCCCTCCTGA
GTGGCTCTCAACATCCGAAACCCGGAGGCAGATCGCCTGGCCGCACAGGTGGCCTGCCTCGCTGGCGAAACCAAATCGGA
TGCTGTGATCCTGGCCCTCAAGGAACGCCTCCAGCGTTCGCTGATCTATCGCCTCGATCAGATTGCCCTGCGCTGTGCGG
CTCGACCGATCCTGGATCTCCGCAGCGCTGACGAGATCTGCGGCTACGACGCCAGCGGCCTTCCCTCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A4P7ZRY2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A4P7ZT40 |