Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 965578..966254 Replicon chromosome
Accession NZ_CP039373
Organism Synechococcus sp. CB0101

Toxin (Protein)


Gene name vapC Uniprot ID A0A4P7ZUZ7
Locus tag CB0101_RS05245 Protein ID WP_010306380.1
Coordinates 965578..965985 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A4P7ZX66
Locus tag CB0101_RS05250 Protein ID WP_010306377.1
Coordinates 965985..966254 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CB0101_RS05220 (CB0101_05205) 961661..963097 - 1437 WP_050778755.1 undecaprenyl-phosphate glucose phosphotransferase -
CB0101_RS05225 (CB0101_05210) 963117..963665 - 549 WP_136643987.1 YdcF family protein -
CB0101_RS05230 (CB0101_05215) 963851..964351 + 501 WP_010306392.1 NUDIX hydrolase -
CB0101_RS05235 (CB0101_05220) 964577..965323 - 747 WP_010306384.1 hypothetical protein -
CB0101_RS05240 (CB0101_05225) 965439..965540 + 102 WP_071778115.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
CB0101_RS05245 (CB0101_05230) 965578..965985 - 408 WP_010306380.1 type II toxin-antitoxin system VapC family toxin Toxin
CB0101_RS05250 (CB0101_05235) 965985..966254 - 270 WP_010306377.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
CB0101_RS05255 (CB0101_05240) 966283..966810 - 528 WP_136644243.1 YdcF family protein -
CB0101_RS05260 (CB0101_05245) 967012..967242 + 231 WP_010306369.1 NUDIX domain-containing protein -
CB0101_RS05265 (CB0101_05250) 967430..968689 - 1260 WP_043717254.1 glycosyltransferase WbuB -
CB0101_RS05270 (CB0101_05255) 968780..969721 - 942 WP_136643988.1 hypothetical protein -
CB0101_RS05275 (CB0101_05260) 969840..970238 - 399 WP_010306355.1 type II toxin-antitoxin system VapC family toxin -
CB0101_RS05280 (CB0101_05265) 970238..970468 - 231 WP_010306351.1 type II toxin-antitoxin system VapB family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-123)

Antitoxin

Antitoxin VapB-like

(2-88)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14627.52 Da        Isoelectric Point: 4.5112

>T123836 WP_010306380.1 NZ_CP039373:c965985-965578 [Synechococcus sp. CB0101]
MVIDPSAVLAILQNEPERPAFNAAIASADHCALSAASLVELSIVIEARYGSDGQGDLDLFLSTAQISIVSLDREQAEIAR
AAFARYGKGRHRASLNLGDCFSYALAQWLEQPLLFKGDDFCHTDLQAAYPVKWAS

Download         Length: 408 bp

>T123836 NZ_CP039373:c965985-965578 [Synechococcus sp. CB0101]
ATGGTGATCGATCCCTCAGCCGTTCTGGCCATCCTCCAGAACGAACCGGAGCGCCCTGCCTTCAATGCAGCCATCGCCAG
TGCCGATCATTGCGCCTTGTCGGCCGCATCCCTCGTGGAACTCTCGATCGTGATCGAGGCCCGGTACGGGTCTGATGGCC
AAGGAGATCTGGATCTGTTTCTCAGCACGGCACAGATCAGCATCGTGAGCCTGGATCGCGAACAGGCCGAAATCGCACGC
GCAGCCTTCGCGCGGTACGGCAAGGGTCGTCATCGCGCAAGCCTCAATCTCGGCGATTGCTTCTCCTATGCTCTGGCCCA
GTGGCTCGAACAACCCCTGCTGTTCAAAGGTGATGATTTCTGCCACACCGATCTCCAAGCTGCTTACCCTGTGAAATGGG
CGTCGTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9623.99 Da        Isoelectric Point: 7.7208

>AT123836 WP_010306377.1 NZ_CP039373:c966254-965985 [Synechococcus sp. CB0101]
VALNIRNPEADRLAAQVACLSGETKTDAVILALKERLQRLQSQPEAGKVRQRSLIHRLDQIALRCAARPILDSSSADEIC
GYDASGLPS

Download         Length: 270 bp

>AT123836 NZ_CP039373:c966254-965985 [Synechococcus sp. CB0101]
GTGGCTCTCAACATCCGAAACCCGGAGGCTGATCGCCTGGCCGCACAGGTGGCCTGCCTTTCTGGAGAAACCAAAACGGA
TGCTGTGATCCTGGCCCTCAAGGAACGCCTCCAGCGTTTGCAGTCCCAGCCCGAGGCGGGCAAGGTCCGGCAGCGTTCGC
TGATCCATCGCCTCGATCAGATTGCCCTGCGCTGTGCGGCTCGACCGATCCTGGATAGCAGCAGCGCTGATGAGATCTGC
GGCTACGACGCCAGCGGCCTTCCCTCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7ZUZ7

Antitoxin

Source ID Structure
AlphaFold DB A0A4P7ZX66

References