Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 4897786..4899470 Replicon chromosome
Accession NZ_CP039371
Organism Pseudomonas putida strain 1290

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag E6B08_RS22640 Protein ID WP_136916057.1
Coordinates 4897786..4898652 (+) Length 289 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag E6B08_RS22645 Protein ID WP_136917475.1
Coordinates 4898658..4899470 (+) Length 271 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E6B08_RS22615 4893755..4894606 + 852 WP_136916052.1 ABC transporter ATP-binding protein -
E6B08_RS22620 4894642..4895643 + 1002 WP_136916053.1 ABC transporter substrate-binding protein -
E6B08_RS22625 4895672..4896448 + 777 WP_136916054.1 ABC transporter permease -
E6B08_RS22630 4896448..4897212 + 765 WP_136916055.1 SDR family oxidoreductase -
E6B08_RS22635 4897227..4897781 + 555 WP_136916056.1 cupin domain-containing protein -
E6B08_RS22640 4897786..4898652 + 867 WP_136916057.1 alpha/beta fold hydrolase Toxin
E6B08_RS22645 4898658..4899470 + 813 WP_136917475.1 IclR family transcriptional regulator Antitoxin
E6B08_RS22650 4899472..4900269 + 798 WP_136916058.1 SDR family oxidoreductase -
E6B08_RS22655 4900262..4901944 + 1683 WP_136916059.1 thiamine pyrophosphate-binding protein -
E6B08_RS22660 4901955..4902758 + 804 WP_136916060.1 aspartate dehydrogenase -
E6B08_RS22665 4902769..4904259 + 1491 WP_136916061.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(41-167)

Antitoxin

Transcription regulator IclR, C-terminal

(131-253)


Sequences

Toxin        


Download         Length: 289 a.a.        Molecular weight: 30291.61 Da        Isoelectric Point: 7.1624

>T123834 WP_136916057.1 NZ_CP039371:4897786-4898652 [Pseudomonas putida]
MSVAETFAAALPDLLPQHFPERLLGLGDSQQAIREAGSGAAIVLLHGIGSGAASWLQVAQGLCHKARVIAWDAPGYGNSA
ALAQARPRAEDYAGRLQSLLDALDIERCVLVGHSLGALTAAAFAQRHPQRVQRLVLLSPARGYGAPAQAEQGRAVRAKRL
DDLARVGIAGLAEARSANLLSPAADARALAWVRWNMARLNPQGYRQAIELLCGDALLDHLPHSVPCEVHCGSADGITRPE
DCRALAEAFAAPFSLINGAGHACAIERPELVTELLARALQASLTGSLQ

Download         Length: 867 bp

>T123834 NZ_CP039371:4897786-4898652 [Pseudomonas putida]
ATGTCGGTTGCCGAAACATTCGCCGCAGCGTTGCCGGACCTGCTCCCGCAACACTTCCCCGAGCGCCTGCTGGGCCTGGG
CGACAGCCAGCAGGCCATCCGCGAAGCGGGCAGCGGCGCGGCCATCGTCCTGCTGCACGGCATCGGCTCGGGCGCGGCGA
GCTGGCTGCAGGTGGCCCAGGGCTTGTGCCACAAGGCGCGGGTCATCGCCTGGGACGCGCCGGGCTACGGCAACTCTGCA
GCGCTGGCACAGGCCCGGCCTCGCGCCGAAGACTACGCCGGACGCCTGCAAAGCCTGCTCGATGCCCTGGATATCGAACG
CTGCGTGCTGGTGGGCCATTCGCTGGGCGCACTGACCGCCGCAGCCTTTGCCCAGCGCCACCCGCAGCGTGTCCAGCGGC
TGGTGCTGCTCAGCCCGGCACGCGGCTATGGCGCGCCGGCACAGGCCGAGCAAGGCCGCGCAGTGCGCGCCAAGCGCCTG
GATGACCTGGCGCGGGTAGGGATCGCCGGCCTCGCCGAAGCACGCAGCGCCAACCTGCTGTCACCTGCCGCCGACGCCCG
CGCGCTGGCCTGGGTGCGCTGGAACATGGCCCGGCTCAACCCCCAGGGTTATCGCCAGGCCATCGAGCTGCTGTGTGGCG
ATGCTTTGCTCGACCACCTGCCCCACAGCGTGCCCTGCGAGGTGCATTGCGGCAGTGCCGACGGCATCACCCGCCCCGAG
GACTGCCGCGCACTGGCTGAAGCCTTCGCGGCGCCCTTCAGCCTGATCAACGGCGCCGGCCATGCCTGCGCCATCGAACG
ACCCGAATTGGTGACCGAGCTCCTGGCCCGGGCACTGCAAGCCTCACTCACAGGTAGCCTGCAATGA

Antitoxin


Download         Length: 271 a.a.        Molecular weight: 29805.16 Da        Isoelectric Point: 6.8693

>AT123834 WP_136917475.1 NZ_CP039371:4898658-4899470 [Pseudomonas putida]
MDASKENQDKYIVPGLERGLLLLCEFSRQNRTLTAPELARRLSLPRSTIFRLLTTLETMGFVNRSGNEYRLGMSVLRLGF
EYLASLELTELGQPLLARLCDHLNYPSNLVVRDGRSIVYVAKVSPPSVFSSAVTVGTRLPAHATVLGRVLLADLSLAELR
ELYPEEHLEQYSPSTPKTVLELFDLVQADRLRGYVNGEGFFESTISTVAAPVRDASGRVTAALGLTIPTVQIGHVNFDNL
LGQVRSSADELSRLLDYRPGSGRVTALMRD

Download         Length: 813 bp

>AT123834 NZ_CP039371:4898658-4899470 [Pseudomonas putida]
ATGGATGCCTCGAAGGAAAACCAGGACAAGTACATTGTCCCCGGCCTGGAGCGCGGCCTGTTGCTGCTGTGCGAATTCAG
CCGGCAGAACCGCACCCTGACCGCACCGGAACTTGCGCGGCGCCTGTCACTGCCACGCTCGACCATCTTCCGCCTGCTGA
CCACCCTGGAAACCATGGGCTTCGTCAACCGCAGCGGCAACGAGTACCGCCTGGGCATGTCGGTGCTGCGCCTGGGCTTC
GAATACCTGGCCTCGCTGGAGTTGACCGAACTCGGCCAACCGCTGCTGGCGCGGCTGTGCGACCACCTCAACTACCCGAG
CAACCTGGTGGTCCGTGACGGTCGCTCGATCGTGTACGTGGCCAAGGTCTCGCCGCCCTCGGTGTTCTCCAGCGCTGTCA
CCGTCGGTACCCGCCTGCCCGCCCACGCCACCGTGCTTGGCCGGGTGCTGCTGGCCGACCTGAGCCTGGCCGAACTGCGC
GAGCTGTACCCCGAGGAGCACCTGGAGCAGTACTCGCCAAGCACGCCGAAAACCGTGCTGGAACTGTTCGACCTAGTCCA
GGCCGATCGCCTGCGCGGTTATGTCAATGGCGAAGGTTTCTTCGAGTCGACCATCTCCACGGTCGCAGCGCCGGTTCGCG
ACGCCAGTGGCCGGGTGACTGCCGCCCTCGGCCTGACCATTCCCACCGTGCAGATCGGCCACGTCAACTTCGACAACCTG
CTGGGCCAGGTACGCAGCAGCGCCGACGAACTGTCGCGGTTGCTCGACTACCGCCCAGGCTCGGGCCGCGTTACCGCGCT
GATGAGGGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References