Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 379515..380120 Replicon chromosome
Accession NZ_CP039371
Organism Pseudomonas putida strain 1290

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag E6B08_RS01830 Protein ID WP_136912523.1
Coordinates 379515..379805 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag E6B08_RS01835 Protein ID WP_136912524.1
Coordinates 379815..380120 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E6B08_RS01805 375153..375908 - 756 WP_136912520.1 ABC transporter substrate-binding protein -
E6B08_RS01810 375920..376693 - 774 WP_136912521.1 ABC transporter ATP-binding protein -
E6B08_RS01820 377312..378697 + 1386 WP_136917314.1 GABA permease -
E6B08_RS01825 378897..379340 - 444 WP_136912522.1 hypothetical protein -
E6B08_RS01830 379515..379805 + 291 WP_136912523.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E6B08_RS01835 379815..380120 + 306 WP_136912524.1 putative addiction module antidote protein Antitoxin
E6B08_RS01845 380399..380671 - 273 WP_133327505.1 oxidative damage protection protein -
E6B08_RS01850 380668..381735 - 1068 WP_136912525.1 A/G-specific adenine glycosylase -
E6B08_RS01855 381732..383963 - 2232 WP_136912526.1 AsmA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 361213..380120 18907


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(46-90)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10771.52 Da        Isoelectric Point: 10.5786

>T123832 WP_136912523.1 NZ_CP039371:379515-379805 [Pseudomonas putida]
MRTLLQTDTYKKWFAGLKDARAQARINVRLRRIELGVMGDCKPVGEGVSELRVDHGPGYRVYFVQRGQEVIILLAGGDKS
SQARDIKSALKLARDL

Download         Length: 291 bp

>T123832 NZ_CP039371:379515-379805 [Pseudomonas putida]
ATGCGCACACTATTACAGACCGACACGTACAAAAAGTGGTTCGCAGGACTCAAGGATGCGCGAGCACAAGCCCGCATTAA
TGTGCGCCTGCGTCGGATTGAGCTTGGGGTGATGGGAGACTGCAAGCCCGTTGGTGAAGGCGTGTCCGAGCTGAGGGTCG
ATCATGGTCCAGGTTATCGGGTGTACTTCGTTCAGCGAGGCCAGGAGGTGATCATTCTGTTGGCAGGTGGCGACAAGTCC
AGCCAGGCCAGAGACATTAAATCCGCACTCAAGTTGGCACGTGATCTATAG

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 10836.54 Da        Isoelectric Point: 5.8347

>AT123832 WP_136912524.1 NZ_CP039371:379815-380120 [Pseudomonas putida]
MTNTKLTKWDAADYLKTGEDMAFYLEACLEENDPALLAAALGDIARARGMAQLARDTGLTREGLYKALSAEGNPSLATIM
KVMAALGVRLHAEVLPRRAVG

Download         Length: 306 bp

>AT123832 NZ_CP039371:379815-380120 [Pseudomonas putida]
ATGACAAATACGAAGCTCACCAAGTGGGATGCTGCAGATTACTTGAAAACCGGGGAAGACATGGCGTTTTACCTGGAGGC
CTGTCTTGAAGAGAACGACCCGGCATTGCTCGCTGCTGCATTGGGCGATATCGCACGCGCACGAGGTATGGCTCAGTTGG
CGCGTGACACTGGGTTGACTCGCGAGGGGTTGTACAAGGCGTTGTCAGCGGAGGGTAATCCGAGCCTGGCGACCATCATG
AAGGTAATGGCGGCGTTGGGCGTGAGGCTGCACGCTGAGGTGCTGCCGCGTCGAGCAGTGGGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References