Detailed information of TA system TA123828

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 473927..474580
• Replicon: chromosome
• Accession: NZ_CP039341
• Organism: Acinetobacter baumannii strain TG31986

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: EA743_RS02390
• Protein ID: WP_000607070.1
• Coordinates: 474191..474580 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: EA743_RS02385
• Protein ID: WP_001288210.1
• Coordinates: 473927..474184 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EA743_RS02365	469443..470450	+	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-
EA743_RS02370	470469..470846	+	378	WP_001216380.1	50S ribosomal protein L17	-
EA743_RS02375	471027..472517	+	1491	WP_000415133.1	NAD(P)/FAD-dependent oxidoreductase	-
EA743_RS02380	472567..473739	-	1173	WP_001190546.1	acyl-CoA dehydrogenase family protein	-
EA743_RS02385	473927..474184	+	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
EA743_RS02390	474191..474580	+	390	WP_000607070.1	hypothetical protein	Toxin
EA743_RS02395	475350..476435	+	1086	WP_000049107.1	hypothetical protein	-
EA743_RS02400	476513..477079	+	567	WP_000651536.1	rhombosortase	-
EA743_RS02405	477267..479462	+	2196	WP_001158905.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15708.02 Da
• Isoelectric Point: 10.3599

>T123828 WP_000607070.1 NZ_CP039341:474191-474580 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAILFYQLMPLLWWLVVISLLFISFIFFLKRPQLAKIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEDHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T123828 NZ_CP039341:474191-474580 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AATTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCAAAAATTGCCTATTTAGATAAAAAACTATGGTCGCTTGCTTATCACTCACAGAACACCATT
TCTCGCGTCAAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGATCTACTTTGAAGATCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT123828 WP_001288210.1 NZ_CP039341:473927-474184 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT123828 NZ_CP039341:473927-474184 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTCGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7