Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 1519590..1520134 Replicon chromosome
Accession NZ_CP039339
Organism Ralstonia solanacearum strain UW386

Toxin (Protein)


Gene name relE Uniprot ID A0A0S4TYB5
Locus tag E7Z57_RS07460 Protein ID WP_064048877.1
Coordinates 1519590..1519865 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0S4TZR3
Locus tag E7Z57_RS07465 Protein ID WP_064048878.1
Coordinates 1519865..1520134 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E7Z57_RS07430 1514827..1515183 - 357 WP_138928814.1 hypothetical protein -
E7Z57_RS07435 1515324..1515614 + 291 WP_138928815.1 helix-turn-helix domain-containing protein -
E7Z57_RS07445 1516108..1517457 + 1350 WP_138929713.1 group II intron reverse transcriptase/maturase -
E7Z57_RS07450 1517558..1518592 + 1035 WP_138928816.1 IS481 family transposase -
E7Z57_RS07455 1518652..1519505 - 854 Protein_1430 IS630 family transposase -
E7Z57_RS07460 1519590..1519865 - 276 WP_064048877.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E7Z57_RS07465 1519865..1520134 - 270 WP_064048878.1 ribbon-helix-helix domain-containing protein Antitoxin
E7Z57_RS07470 1520181..1520483 - 303 WP_081261885.1 hypothetical protein -
E7Z57_RS07475 1520953..1521732 - 780 WP_064048879.1 alpha/beta hydrolase -
E7Z57_RS07480 1521864..1522761 + 898 Protein_1435 LysR family transcriptional regulator -
E7Z57_RS07485 1523134..1523619 - 486 WP_064048880.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1508682..1523673 14991


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-46)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10647.27 Da        Isoelectric Point: 9.5285

>T123822 WP_064048877.1 NZ_CP039339:c1519865-1519590 [Ralstonia solanacearum]
MEVKWTGKAVSDITRLYEFLSQVNTPAAVRVVQSLTGAPKSLVVNPRIGEQLDEFEPREVRRIIVGQYEMRYEIRGSVIY
VLRLWHTREDR

Download         Length: 276 bp

>T123822 NZ_CP039339:c1519865-1519590 [Ralstonia solanacearum]
ATGGAGGTCAAGTGGACTGGCAAAGCGGTATCGGACATCACGCGCCTGTACGAATTTCTCTCACAGGTCAACACGCCTGC
GGCTGTCCGCGTAGTGCAATCCCTGACTGGCGCACCGAAATCGTTGGTGGTGAACCCGCGTATTGGTGAGCAGTTAGATG
AGTTCGAACCGCGCGAGGTTCGTCGCATCATCGTGGGTCAGTATGAGATGCGGTATGAGATTCGCGGCTCGGTCATTTAC
GTGCTGCGTTTGTGGCATACGCGCGAGGATCGCTAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10024.33 Da        Isoelectric Point: 6.7272

>AT123822 WP_064048878.1 NZ_CP039339:c1520134-1519865 [Ralstonia solanacearum]
MAHPDTRVLTAHVPVQLAERVDQIAERLERSRGWIMKQALSAWIEQEEERSRLTREALADVDAGAVIDHQAVQAWADSLS
TSKPKKAPR

Download         Length: 270 bp

>AT123822 NZ_CP039339:c1520134-1519865 [Ralstonia solanacearum]
ATGGCCCATCCTGACACCCGCGTGCTTACCGCCCATGTGCCGGTACAGTTGGCGGAACGAGTCGATCAGATTGCGGAGCG
CCTTGAGCGGTCACGTGGTTGGATCATGAAACAAGCACTCTCTGCCTGGATCGAGCAGGAAGAAGAGCGTAGCCGGTTGA
CGCGTGAGGCATTGGCCGATGTGGACGCTGGCGCGGTGATCGACCATCAGGCCGTGCAAGCGTGGGCGGATAGCCTTTCG
ACAAGCAAACCGAAAAAGGCGCCGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0S4TYB5

Antitoxin

Source ID Structure
AlphaFold DB A0A0S4TZR3

References