Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 4674010..4674598 Replicon chromosome
Accession NZ_CP039327
Organism Citrobacter portucalensis strain Effluent_1

Toxin (Protein)


Gene name PumA Uniprot ID A0A5B0T4T9
Locus tag E7703_RS22950 Protein ID WP_032942059.1
Coordinates 4674010..4674327 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A5B0STC7
Locus tag E7703_RS22955 Protein ID WP_032942057.1
Coordinates 4674320..4674598 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E7703_RS22925 4669178..4670401 + 1224 WP_048215146.1 L-sorbose 1-phosphate reductase -
E7703_RS22930 4670403..4671215 + 813 WP_032942070.1 shikimate 5-dehydrogenase -
E7703_RS22935 4671265..4671618 - 354 WP_136392423.1 hypothetical protein -
E7703_RS22940 4671804..4673042 + 1239 WP_012291449.1 IS110 family transposase -
E7703_RS22945 4673195..4673746 + 552 WP_136392424.1 AAA family ATPase -
E7703_RS22950 4674010..4674327 + 318 WP_032942059.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E7703_RS22955 4674320..4674598 + 279 WP_032942057.1 putative addiction module antidote protein Antitoxin
E7703_RS22960 4674709..4675398 + 690 WP_032942056.1 dipeptidase PepE -
E7703_RS22965 4675565..4677196 - 1632 WP_048213962.1 Na/Pi cotransporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-95)

Antitoxin

Uncharacterized protein HI1420

(3-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11993.00 Da        Isoelectric Point: 9.6790

>T123815 WP_032942059.1 NZ_CP039327:4674010-4674327 [Citrobacter portucalensis]
IMEILQTMVFRRWEQNLRDRRAKTLIATRLFRLANGLAGDVKPVGEGVSEMRISYGPGYRIYFKQQGCRIIILLCGGDKS
SQANDITLAKMLARTLDSQEIFCHE

Download         Length: 318 bp

>T123815 NZ_CP039327:4674010-4674327 [Citrobacter portucalensis]
ATCATGGAAATTCTTCAGACAATGGTTTTCCGGCGTTGGGAGCAAAACCTACGGGACAGGAGAGCTAAAACGCTCATTGC
CACACGCCTTTTTCGTCTGGCTAATGGTTTAGCTGGTGATGTTAAACCTGTTGGGGAAGGCGTCAGCGAAATGCGCATTT
CTTACGGTCCTGGCTACAGGATTTACTTTAAACAGCAAGGTTGCCGCATCATCATTTTGTTATGTGGGGGCGATAAAAGC
TCACAAGCCAACGATATTACTCTTGCAAAAATGCTCGCCCGTACACTGGATTCACAGGAGATCTTCTGCCATGAATAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 9872.45 Da        Isoelectric Point: 5.8233

>AT123815 WP_032942057.1 NZ_CP039327:4674320-4674598 [Citrobacter portucalensis]
MNKLTHYDPATALVDDEEIAVFMADALETGDAAYIAKALGVVARAKGMANIAAETGLSREQLYRSFSEKGNPTLKTTLAV
MKVLGIELTLKK

Download         Length: 279 bp

>AT123815 NZ_CP039327:4674320-4674598 [Citrobacter portucalensis]
ATGAATAAACTTACTCACTACGATCCCGCGACTGCGCTGGTTGATGATGAAGAAATTGCCGTGTTTATGGCCGATGCCCT
CGAAACAGGCGATGCAGCATACATTGCAAAAGCACTGGGCGTGGTAGCTCGCGCTAAGGGAATGGCGAACATTGCGGCAG
AAACGGGATTATCCCGCGAGCAGCTTTATCGCTCTTTTAGTGAGAAAGGTAACCCGACGCTGAAAACCACCCTTGCAGTG
ATGAAGGTACTCGGCATTGAATTGACACTTAAAAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5B0T4T9

Antitoxin

Source ID Structure
AlphaFold DB A0A5B0STC7

References