Detailed information of TA system TA123814

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 4573544..4574079
• Replicon: chromosome
• Accession: NZ_CP039327
• Organism: Citrobacter portucalensis strain Effluent_1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: E7703_RS22475
• Protein ID: WP_048227467.1
• Coordinates: 4573792..4574079 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: D4BKM9
• Locus tag: E7703_RS22470
• Protein ID: WP_006688247.1
• Coordinates: 4573544..4573795 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E7703_RS22445	4569901..4570587	+	687	WP_003826708.1	phosphonate C-P lyase system protein PhnL	-
E7703_RS22450	4570584..4571720	+	1137	WP_048227465.1	alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase	-
E7703_RS22455	4571723..4572277	+	555	WP_048215112.1	ribose 1,5-bisphosphokinase	-
E7703_RS22460	4572264..4572698	+	435	WP_048215113.1	aminoalkylphosphonate N-acetyltransferase	-
E7703_RS22465	4572707..4573465	+	759	WP_048227466.1	phosphonate metabolism protein PhnP	-
E7703_RS22470	4573544..4573795	+	252	WP_006688247.1	plasmid stabilization protein	Antitoxin
E7703_RS22475	4573792..4574079	+	288	WP_048227467.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
E7703_RS22480	4574076..4574405	-	330	WP_003031807.1	hypothetical protein	-
E7703_RS22485	4574475..4576739	-	2265	WP_136392400.1	hybrid sensor histidine kinase/response regulator	-
E7703_RS22495	4576854..4578377	+	1524	WP_136392401.1	sugar ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-86)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11165.14 Da
• Isoelectric Point: 10.3527

>T123814 WP_048227467.1 NZ_CP039327:4573792-4574079 [Citrobacter portucalensis]
MSYTVKFREDALKEWQKLDKAIQQQFAKKLKKCCENPHIPSAKLRGIKDCYKIKLRTSGFRLVYQVIDDTLVIVVVAVGK
RERSEVYNLASERFR

Nucleotide

• Length: 288 bp

>T123814 NZ_CP039327:4573792-4574079 [Citrobacter portucalensis]
ATGAGTTATACGGTAAAGTTCAGGGAAGATGCGCTGAAAGAATGGCAAAAACTTGATAAAGCCATTCAGCAGCAATTTGC
CAAAAAACTAAAGAAATGCTGTGAAAATCCGCATATTCCTTCAGCAAAGCTCAGGGGAATAAAAGATTGCTACAAAATCA
AACTACGAACATCAGGGTTTCGTCTTGTTTATCAAGTCATTGACGACACCCTGGTCATCGTGGTCGTTGCCGTCGGTAAA
CGCGAGCGTAGTGAAGTCTATAATCTTGCCAGCGAAAGATTTCGCTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9215.53 Da
• Isoelectric Point: 4.2965

>AT123814 WP_006688247.1 NZ_CP039327:4573544-4573795 [Citrobacter portucalensis]
MPHIILSDTTASVSELKKNPMATVSAGDGFPVAILNRNQPAFYCVPAELYEKMLDALDDQQLVKLVHERSQQPLVDVDLD
SYL

Nucleotide

• Length: 252 bp

>AT123814 NZ_CP039327:4573544-4573795 [Citrobacter portucalensis]
ATGCCGCATATCATTTTAAGCGATACCACCGCGAGTGTGAGTGAGCTAAAAAAGAACCCGATGGCGACTGTTAGCGCAGG
AGATGGGTTTCCGGTCGCAATTCTGAACCGTAACCAGCCCGCTTTTTATTGCGTGCCAGCAGAGCTTTACGAAAAAATGC
TCGATGCGCTGGACGATCAACAGCTGGTTAAATTAGTCCATGAACGTAGCCAACAACCCCTGGTGGATGTGGATCTGGAC
AGCTACTTATGA

Structures

Antitoxin

• AlphaFold DB: A0A7X1BT32