Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1231926..1232546 Replicon chromosome
Accession NZ_CP039327
Organism Citrobacter portucalensis strain Effluent_1

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag E7703_RS05980 Protein ID WP_002892050.1
Coordinates 1231926..1232144 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID R8WZW8
Locus tag E7703_RS05985 Protein ID WP_003021733.1
Coordinates 1232172..1232546 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E7703_RS05945 1227284..1227913 + 630 WP_048214785.1 membrane protein -
E7703_RS05950 1227978..1228331 + 354 WP_048226278.1 DUF1428 family protein -
E7703_RS05955 1228383..1229936 - 1554 WP_136391583.1 EAL domain-containing protein -
E7703_RS05960 1230125..1230385 + 261 WP_008783961.1 type B 50S ribosomal protein L31 -
E7703_RS05965 1230387..1230527 + 141 WP_005125190.1 type B 50S ribosomal protein L36 -
E7703_RS05970 1230606..1231076 - 471 WP_063941318.1 YlaC family protein -
E7703_RS05975 1231193..1231744 - 552 WP_003835924.1 maltose O-acetyltransferase -
E7703_RS05980 1231926..1232144 - 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
E7703_RS05985 1232172..1232546 - 375 WP_003021733.1 Hha toxicity modulator TomB Antitoxin
E7703_RS05990 1233034..1236183 - 3150 WP_003021736.1 multidrug efflux RND transporter permease subunit -
E7703_RS05995 1236206..1237399 - 1194 WP_048226274.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T123801 WP_002892050.1 NZ_CP039327:c1232144-1231926 [Citrobacter portucalensis]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T123801 NZ_CP039327:c1232144-1231926 [Citrobacter portucalensis]
ATGTCCGATAAACCATTAACTAAAACAGATTATTTGATGCGCCTGCGACGTTGCCAGACAATTGATACGCTAGAGCGCGT
TATTGAAAAAAATAAATATGAATTGTCCGACAACGAACTGGCTGTATTTTACTCAGCAGCAGATCATCGCCTTGCTGAAT
TGACCATGAATAAGCTTTACGACAAGATTCCAACTTCTGTTTGGAAATTCATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14427.23 Da        Isoelectric Point: 5.5653

>AT123801 WP_003021733.1 NZ_CP039327:c1232546-1232172 [Citrobacter portucalensis]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT123801 NZ_CP039327:c1232546-1232172 [Citrobacter portucalensis]
ATGGATGAGTACTCACCCAAAAGACATGATATCGCGCAGCTTAAATTTCTCTGCGAAACTCTGTATCATGACTGTCTTGC
AAACCTTGAACAAAGTAACCATGGCTGGGTTAATGACCCTACCTCTGCAACCAGCTTGCAGCTCAATGAACTGATAGAGC
ATATTGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAGGACAATAAGCTGATCGCGCAGATAGATGAATACCTG
GATGACACTTTTATGTTGTTCAGCAGTTATGGTATTAATACGCAGGATCTGCAGAAATGGCGGAAGTCAGGTAATCGACT
GTTTCGCTGTTTTGTCAATGCCACCAGGGCTAATCCTGTAAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB R8WZW8

References