Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 600044..600560 Replicon chromosome
Accession NZ_CP039327
Organism Citrobacter portucalensis strain Effluent_1

Toxin (Protein)


Gene name relE Uniprot ID A0A6H3ATC4
Locus tag E7703_RS03015 Protein ID WP_048227188.1
Coordinates 600276..600560 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A6H3AWC7
Locus tag E7703_RS03010 Protein ID WP_003830370.1
Coordinates 600044..600286 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E7703_RS02990 595059..596192 + 1134 WP_136391449.1 amidohydrolase/deacetylase family metallohydrolase -
E7703_RS02995 596176..597294 + 1119 WP_136391450.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
E7703_RS03000 597291..598031 + 741 WP_048215061.1 KDGP aldolase family protein -
E7703_RS03005 598053..599966 + 1914 WP_136391451.1 BglG family transcription antiterminator -
E7703_RS03010 600044..600286 + 243 WP_003830370.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
E7703_RS03015 600276..600560 + 285 WP_048227188.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E7703_RS03020 600564..601028 - 465 WP_048227187.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
E7703_RS03025 601149..603287 - 2139 WP_048215057.1 anaerobic ribonucleoside-triphosphate reductase -
E7703_RS03030 603696..605348 - 1653 WP_136391452.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-65)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10918.71 Da        Isoelectric Point: 10.0482

>T123800 WP_048227188.1 NZ_CP039327:600276-600560 [Citrobacter portucalensis]
MTYELEFDPRALKEWHKLGDTVKTQFKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVVVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T123800 NZ_CP039327:600276-600560 [Citrobacter portucalensis]
ATGACTTATGAGCTGGAATTCGACCCGAGAGCCTTAAAAGAGTGGCATAAACTGGGTGATACGGTGAAGACTCAGTTTAA
GAAGAAGTTGGCCGACGTGTTGTTGAACCCCAGAATTGACTCTGCCCGTTTAAATGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGGTACCGTCTGGTGTACCAGGTTCGGGATGAGGTTGTGGTCGTGTTTGTTGTCGCGGTAGGTAAG
CGAGAACATTCAGCCGTTTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8945.35 Da        Isoelectric Point: 5.0651

>AT123800 WP_003830370.1 NZ_CP039327:600044-600286 [Citrobacter portucalensis]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLASPQKGIKVSLDDL

Download         Length: 243 bp

>AT123800 NZ_CP039327:600044-600286 [Citrobacter portucalensis]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAATATTACTCC
AACGGAAGCTGTGCGATTACTGTTTCAGTACGTCGCGGAAACGGGGCGCATGCCGGTGAAAACCGTCACCCTTAGCGACA
GTGAAGATGCACTCATTCAGACAGTCCGGGAAAGGCTTGCCAGCCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6H3ATC4

Antitoxin

Source ID Structure
AlphaFold DB A0A6H3AWC7

References