Detailed information of TA system TA123798

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelE-RHH
• Location: 1988..2535
• Replicon: plasmid unnamed1
• Accession: NZ_CP039299
• Organism: Escherichia coli strain PigCaeca_1

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: E7Z58_RS23395
• Protein ID: WP_136360490.1
• Coordinates: 2254..2535 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: E7Z58_RS23390
• Protein ID: WP_063848275.1
• Coordinates: 1988..2257 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E7Z58_RS23375	46..1077	+	1032	WP_136360489.1	replication initiation protein	-
E7Z58_RS24450	1775..1933	+	159	WP_001470858.1	hypothetical protein	-
E7Z58_RS23390	1988..2257	+	270	WP_063848275.1	hypothetical protein	Antitoxin
E7Z58_RS23395	2254..2535	+	282	WP_136360490.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
E7Z58_RS23400	2581..3192	+	612	Protein_4	3'-5' exonuclease	-
E7Z58_RS23405	3333..4506	-	1174	Protein_5	IS91 family transposase	-
E7Z58_RS23410	4469..4870	-	402	WP_000124097.1	hypothetical protein	-
E7Z58_RS23415	4959..5243	+	285	Protein_7	3'-5' exonuclease	-
E7Z58_RS23420	5360..5842	+	483	WP_001402899.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	qnrS1	-	1..105771	105771

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-92)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10874.59 Da
• Isoelectric Point: 9.7617

>T123798 WP_136360490.1 NZ_CP039299:2254-2535 [Escherichia coli]
MMEIFWTILASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVKGTRELVIHPHFVLVYEVDSQWGKV
YILRVLHTAQKWP

Nucleotide

• Length: 282 bp

>T123798 NZ_CP039299:2254-2535 [Escherichia coli]
ATGATGGAGATATTCTGGACCATACTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGAT
GGCCGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGTAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTC
GTGTGAAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGTCAGTGGGGAAAAGTG
TATATCCTGCGTGTATTGCATACTGCACAGAAGTGGCCATAG

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10210.55 Da
• Isoelectric Point: 8.8735

>AT123798 WP_063848275.1 NZ_CP039299:1988-2257 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLGRGDVLPHDMVESSAAAWRD
EMSRKVTGK

Nucleotide

• Length: 270 bp

>AT123798 NZ_CP039299:1988-2257 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
AGGCAGGACGTCAGCAACTCGGGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTTACCGGTAAATGA