Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) slvAT/RES(toxin)
Location 395540..396456 Replicon plasmid pPABL048
Accession NZ_CP039294
Organism Pseudomonas aeruginosa strain PABL048

Toxin (Protein)


Gene name slvT Uniprot ID A0A2L1KI32
Locus tag DZ927_RS35415 Protein ID WP_019437783.1
Coordinates 395540..396064 (-) Length 175 a.a.

Antitoxin (Protein)


Gene name slvA Uniprot ID A0A2L1KH13
Locus tag DZ927_RS35420 Protein ID WP_019437782.1
Coordinates 396061..396456 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DZ927_RS35390 390784..391929 + 1146 WP_019437787.1 glycerate kinase -
DZ927_RS35400 392349..392540 - 192 WP_019437785.1 hypothetical protein -
DZ927_RS35405 392915..393910 + 996 WP_079744282.1 prepilin-type N-terminal cleavage/methylation domain-containing protein -
DZ927_RS35410 394244..395494 + 1251 WP_019437784.1 TerD family protein -
DZ927_RS35415 395540..396064 - 525 WP_019437783.1 RES family NAD+ phosphorylase Toxin
DZ927_RS35420 396061..396456 - 396 WP_019437782.1 hypothetical protein Antitoxin
DZ927_RS35425 397041..398924 - 1884 WP_100247856.1 helicase -
DZ927_RS35435 400236..400535 + 300 WP_136342214.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid sul1 / qacE / aadA10 / blaOXA-10 / ant(2'')-Ia - 1..414954 414954


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(10-167)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 175 a.a.        Molecular weight: 19052.57 Da        Isoelectric Point: 4.5535

>T123747 WP_019437783.1 NZ_CP039294:c396064-395540 [Pseudomonas aeruginosa]
MKIIGVQDLPCYRMHTPKWSVAPTSGAGAATQGGRVNRKGLEALYLSLESATAIAEFQQASAFLPPGLLISYSLSLDRVI
DFTGGYNDTWAPIWQDFFCDWRKIRFNDGVEPPSWIIGDLAIEADCAGILFESVANPGGRNLVLFTDQLPVHGNIVVNDP
RGDLPTDQSSWTRP

Download         Length: 525 bp

>T123747 NZ_CP039294:c396064-395540 [Pseudomonas aeruginosa]
ATGAAAATCATCGGAGTGCAGGACCTCCCCTGCTACCGAATGCACACTCCCAAGTGGTCCGTTGCGCCTACATCTGGAGC
TGGAGCTGCAACTCAGGGTGGCCGGGTTAACCGAAAGGGGCTAGAGGCTCTATACCTCTCGCTTGAGTCGGCAACGGCCA
TTGCTGAGTTTCAGCAAGCAAGCGCATTCCTTCCTCCTGGTCTGCTGATCAGCTATTCCCTCAGTCTGGATCGAGTGATC
GACTTCACCGGCGGCTATAACGATACCTGGGCCCCGATCTGGCAAGACTTCTTCTGCGACTGGAGAAAGATTCGCTTCAA
CGACGGCGTTGAACCGCCGAGCTGGATTATCGGGGATCTGGCTATCGAGGCTGACTGTGCTGGGATTCTGTTCGAGTCCG
TTGCGAACCCTGGAGGTCGGAACCTGGTGCTTTTCACCGATCAGTTGCCGGTGCATGGGAATATTGTGGTCAACGATCCT
CGCGGGGATCTCCCTACCGACCAGTCATCTTGGACGCGCCCGTAG

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14753.87 Da        Isoelectric Point: 7.2048

>AT123747 WP_019437782.1 NZ_CP039294:c396456-396061 [Pseudomonas aeruginosa]
MASKAVLELRPTNFAGLMDALKEVNRVMFSPERFLKVFSMDQQTLALRAHVHRNTVRNAPESEKVQAYIRDSVKVLRAVT
DMGTDVTNAIFWFKNEPLSTFGYKTAEEVVSEGKTEQLIAFLQSWEAGAQG

Download         Length: 396 bp

>AT123747 NZ_CP039294:c396456-396061 [Pseudomonas aeruginosa]
ATGGCCAGCAAAGCCGTATTAGAGCTTCGCCCCACCAACTTCGCGGGCTTGATGGACGCTCTCAAAGAGGTGAACCGTGT
GATGTTCTCTCCTGAGCGCTTCCTCAAGGTTTTTTCGATGGACCAGCAGACCTTGGCGCTCCGGGCCCATGTCCATCGCA
ACACTGTGCGCAACGCGCCTGAATCGGAAAAGGTCCAGGCCTACATTCGTGATTCAGTGAAGGTTCTGCGCGCAGTGACC
GACATGGGCACGGACGTGACGAATGCCATCTTCTGGTTTAAGAACGAGCCTCTTTCCACGTTCGGCTATAAGACCGCGGA
GGAAGTGGTCAGCGAAGGAAAAACCGAGCAGCTGATCGCTTTCCTTCAATCTTGGGAAGCTGGTGCCCAAGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2L1KI32

Antitoxin

Source ID Structure
AlphaFold DB A0A2L1KH13

References