Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 5181714..5182322 Replicon chromosome
Accession NZ_CP039293
Organism Pseudomonas aeruginosa strain PABL048

Toxin (Protein)


Gene name PfiT Uniprot ID A0A444LUU5
Locus tag DZ927_RS24985 Protein ID WP_019486378.1
Coordinates 5181714..5182061 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag DZ927_RS24990 Protein ID WP_003114155.1
Coordinates 5182071..5182322 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DZ927_RS24965 5177648..5178079 + 432 WP_023084996.1 phosphate-starvation-inducible PsiE family protein -
DZ927_RS24970 5178123..5179088 + 966 WP_003141083.1 M48 family metalloprotease -
DZ927_RS24975 5179113..5180264 + 1152 WP_012761372.1 trypsin-like peptidase domain-containing protein -
DZ927_RS24980 5180497..5181405 + 909 WP_003141085.1 LysR family transcriptional regulator -
DZ927_RS24985 5181714..5182061 - 348 WP_019486378.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DZ927_RS24990 5182071..5182322 - 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DZ927_RS24995 5182536..5183519 - 984 WP_003114154.1 tyrosine-type recombinase/integrase -
DZ927_RS25000 5183519..5184811 - 1293 WP_003115206.1 hypothetical protein -
DZ927_RS25005 5185070..5186332 - 1263 WP_019486376.1 hypothetical protein -
DZ927_RS25010 5186334..5186684 - 351 WP_003133726.1 DUF2523 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 5080588..5222560 141972


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12956.72 Da        Isoelectric Point: 4.4212

>T123744 WP_019486378.1 NZ_CP039293:c5182061-5181714 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAALQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEAAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

>T123744 NZ_CP039293:c5182061-5181714 [Pseudomonas aeruginosa]
ATGTCCCCGGTCGTCATTCGTTTTACTGATACCGCAGAGCAAAGCATCGAAGACCAAGTCCACCACTTGGCTCCATTCCA
AGGTGAACAGGCTGCACTCCAGTCAGTACTGAGCCTTTTGGATGAGATTGAAGAGAAGATTTCACTTGCACCTAAAGGTT
ACCCAGTCAGCCAGCAGGCGAGTCTTCTGGGGGTGCTGAGCTATCGCGAGCTTAATACCGGCCCCTATCGTGTTTTTTAC
GAATTCCACGAAGAGCAAGGCGAGGCGGCAGTGATCTTGGTTCTGCGACAGAAGCAGAGTGTTGAGCAGCAATTGATCCG
CTACTGCTTGGTGGGGCCAATCGAGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT123744 WP_003114155.1 NZ_CP039293:c5182322-5182071 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp

>AT123744 NZ_CP039293:c5182322-5182071 [Pseudomonas aeruginosa]
ATGCGAGTCGAGACAATTAGTTATTTGAAACGTCATGCGGCTGACCTGGACTTATCCGAGCCAATGGTCGTCACGCAGAA
CGGTGTTCCTGCCTATGTGGTTGAGTCATATGCTGAGCGGAAGCAGCGCGATGAAGCAATTGCGCTGGTGAAGTTGCTTG
CGATTGGCTCCCGCCAGTACGCAGAAGGCAAGCATCGCTCTGTTGATGATTTGAAAGCTCGCCTTTCCAGGAGGTTCGCT
CAGCCAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A444LUU5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References