Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 5154886..5155459 Replicon chromosome
Accession NZ_CP039293
Organism Pseudomonas aeruginosa strain PABL048

Toxin (Protein)


Gene name relE Uniprot ID W5IUR0
Locus tag DZ927_RS24845 Protein ID WP_009618209.1
Coordinates 5154886..5155173 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID W5ISI7
Locus tag DZ927_RS24850 Protein ID WP_009618210.1
Coordinates 5155160..5155459 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DZ927_RS24820 5150528..5152543 - 2016 WP_013982117.1 DNA topoisomerase III -
DZ927_RS24825 5152838..5153221 - 384 WP_004362284.1 single-stranded DNA-binding protein -
DZ927_RS24830 5153218..5153766 - 549 WP_031641644.1 DUF3158 family protein -
DZ927_RS24835 5153763..5154542 - 780 WP_013982115.1 TIGR03761 family integrating conjugative element protein -
DZ927_RS24840 5154666..5154857 - 192 WP_011805449.1 hypothetical protein -
DZ927_RS24845 5154886..5155173 - 288 WP_009618209.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DZ927_RS24850 5155160..5155459 - 300 WP_009618210.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
DZ927_RS24855 5155587..5156780 - 1194 WP_013982114.1 hypothetical protein -
DZ927_RS24860 5156783..5157343 - 561 WP_013982113.1 DUF2857 domain-containing protein -
DZ927_RS24865 5157361..5159019 - 1659 WP_013982112.1 ParB family protein -
DZ927_RS24870 5159012..5159248 - 237 WP_013982111.1 type II toxin-antitoxin system HicA family toxin -
DZ927_RS24875 5159232..5160098 - 867 WP_013982110.1 ParA family protein -
DZ927_RS24880 5160139..5160357 - 219 WP_023084999.1 AlpA family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 5080588..5222560 141972


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-58)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10854.46 Da        Isoelectric Point: 8.4628

>T123743 WP_009618209.1 NZ_CP039293:c5155173-5154886 [Pseudomonas aeruginosa]
VRVLEWREAARADLLAIVDYISDDNPDAAQRLKDDIEAKAAKLPERPKLYRPGRVAGTREMVVRANYVVVYMEDTRAVSI
LRVLHAAQQWPPARE

Download         Length: 288 bp

>T123743 NZ_CP039293:c5155173-5154886 [Pseudomonas aeruginosa]
GTGCGCGTACTTGAGTGGCGGGAAGCTGCCCGCGCCGACCTGCTGGCGATTGTTGACTACATCTCGGACGACAACCCCGA
TGCCGCGCAGCGGTTGAAGGACGACATCGAGGCCAAGGCCGCGAAGCTGCCGGAGCGCCCGAAGCTCTACCGGCCTGGCC
GCGTGGCCGGCACGCGGGAGATGGTCGTGCGTGCGAACTACGTGGTGGTCTACATGGAGGACACCCGCGCGGTGTCCATC
CTGCGCGTGTTGCACGCCGCGCAGCAGTGGCCGCCGGCACGGGAGTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10816.46 Da        Isoelectric Point: 8.6579

>AT123743 WP_009618210.1 NZ_CP039293:c5155459-5155160 [Pseudomonas aeruginosa]
MAAQTSMLHIRVDDKLKADAAEKLAGVGLTVSDAVRILLTRVVKEGALPAGLTADPEAYDAWFRAKVQEALADTRPPVPH
QQVMDEAQALIDRKRRART

Download         Length: 300 bp

>AT123743 NZ_CP039293:c5155459-5155160 [Pseudomonas aeruginosa]
ATGGCCGCACAGACTTCGATGCTGCACATCCGCGTGGACGATAAGCTCAAGGCCGATGCAGCCGAGAAACTCGCCGGGGT
CGGCCTCACCGTTTCGGACGCCGTGCGCATCCTGCTGACCCGTGTGGTCAAGGAAGGCGCACTGCCGGCTGGCCTCACGG
CCGACCCGGAGGCCTACGATGCCTGGTTCCGGGCGAAGGTCCAGGAGGCGCTGGCCGACACACGGCCGCCGGTGCCGCAC
CAGCAGGTCATGGATGAGGCGCAGGCCCTGATCGACAGGAAGCGGCGTGCGCGTACTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5R9QF16

Antitoxin

Source ID Structure
AlphaFold DB A0A5R9QE11

References