Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 2831200..2831851 Replicon chromosome
Accession NZ_CP039293
Organism Pseudomonas aeruginosa strain PABL048

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag DZ927_RS14020 Protein ID WP_019486655.1
Coordinates 2831672..2831851 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag DZ927_RS14015 Protein ID WP_019486656.1
Coordinates 2831200..2831631 (-) Length 144 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DZ927_RS13975 2826512..2827207 - 696 WP_171946357.1 helix-turn-helix transcriptional regulator -
DZ927_RS13980 2827290..2827493 + 204 WP_031692832.1 helix-turn-helix domain-containing protein -
DZ927_RS13985 2827496..2827810 + 315 WP_019396727.1 hypothetical protein -
DZ927_RS13990 2827811..2828824 + 1014 WP_019486661.1 hypothetical protein -
DZ927_RS13995 2828952..2829362 + 411 WP_025991903.1 hypothetical protein -
DZ927_RS14000 2829355..2829657 + 303 WP_019486659.1 hypothetical protein -
DZ927_RS14005 2829654..2830100 + 447 WP_019486658.1 RusA family crossover junction endodeoxyribonuclease -
DZ927_RS14010 2830223..2831110 + 888 WP_019486657.1 hypothetical protein -
DZ927_RS14015 2831200..2831631 - 432 WP_019486656.1 transcriptional regulator Antitoxin
DZ927_RS14020 2831672..2831851 - 180 WP_019486655.1 type II toxin-antitoxin system HicA family toxin Toxin
DZ927_RS14025 2831940..2832155 + 216 WP_019486654.1 hypothetical protein -
DZ927_RS14030 2832298..2832687 + 390 WP_019486653.1 hypothetical protein -
DZ927_RS14035 2832680..2832964 + 285 WP_019486652.1 phage holin family protein -
DZ927_RS14040 2832964..2833476 + 513 WP_019486651.1 glycoside hydrolase family 104 protein -
DZ927_RS14045 2833473..2833664 + 192 WP_019486650.1 hypothetical protein -
DZ927_RS14050 2833654..2834034 + 381 WP_019486649.1 hypothetical protein -
DZ927_RS14055 2834063..2834293 - 231 WP_019486648.1 hypothetical protein -
DZ927_RS14060 2834401..2834982 + 582 WP_019486647.1 hypothetical protein -
DZ927_RS14065 2835056..2836537 + 1482 Protein_2713 terminase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(11-78)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6605.65 Da        Isoelectric Point: 11.1475

>T123740 WP_019486655.1 NZ_CP039293:c2831851-2831672 [Pseudomonas aeruginosa]
MKFSEFRRWLRAQGVTFEAGKGSHFKVTAPNGKTTTFADHGAKEMPEPTRKAIIKQLGL

Download         Length: 180 bp

>T123740 NZ_CP039293:c2831851-2831672 [Pseudomonas aeruginosa]
ATGAAGTTCAGCGAATTCCGACGCTGGCTGAGGGCACAAGGTGTGACCTTCGAAGCCGGCAAGGGCAGTCACTTCAAGGT
GACCGCCCCGAACGGTAAGACAACGACCTTCGCAGATCACGGCGCCAAAGAAATGCCGGAGCCGACACGCAAGGCGATCA
TCAAGCAACTGGGGCTCTGA

Antitoxin


Download         Length: 144 a.a.        Molecular weight: 15862.17 Da        Isoelectric Point: 4.7692

>AT123740 WP_019486656.1 NZ_CP039293:c2831631-2831200 [Pseudomonas aeruginosa]
MYNFAIRFEQDDSAPGVAVFCRDLPELNSYGNTVEHALGEAVDAIETTLSLYVDQRRPIPAASAPEPEEHVVHLPAVTVA
KIALWNEMMRRDMRKADLCRALGVAQVQVDRLVDFLHTSKMEQLESALGVLGLRLFVSVQQAA

Download         Length: 432 bp

>AT123740 NZ_CP039293:c2831631-2831200 [Pseudomonas aeruginosa]
ATGTACAACTTCGCAATCCGTTTCGAGCAAGACGACAGCGCTCCTGGCGTTGCCGTTTTCTGTCGAGACCTTCCAGAGCT
GAACAGCTACGGAAACACCGTCGAGCACGCACTCGGCGAGGCCGTTGATGCCATCGAAACCACATTGTCGCTCTACGTTG
ATCAGCGCCGACCAATTCCAGCGGCTAGCGCTCCAGAACCAGAAGAGCACGTAGTGCATCTTCCAGCGGTGACCGTCGCG
AAGATCGCTCTATGGAACGAGATGATGCGGCGCGACATGCGGAAGGCTGATCTATGCCGGGCTCTAGGCGTCGCCCAAGT
ACAGGTCGACCGCCTCGTCGACTTTCTGCATACCTCGAAGATGGAGCAGTTGGAGTCCGCGTTAGGGGTCTTAGGCTTGC
GTCTTTTCGTGAGTGTGCAGCAGGCTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References