123737

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 152019..152524 Replicon chromosome
Accession NZ_CP039293
Organism Pseudomonas aeruginosa strain PABL048

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag DZ927_RS00720 Protein ID WP_003083773.1
Coordinates 152019..152300 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag DZ927_RS00725 Protein ID WP_003083775.1
Coordinates 152297..152524 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DZ927_RS00695 147270..148619 + 1350 WP_003137006.1 C4-dicarboxylate transporter DctA -
DZ927_RS00700 148668..149354 + 687 WP_003083762.1 FadR family transcriptional regulator -
DZ927_RS00705 149455..150189 + 735 WP_003110658.1 GntR family transcriptional regulator -
DZ927_RS00710 150393..150779 + 387 WP_003083767.1 aegerolysin family protein -
DZ927_RS00715 150811..151719 - 909 WP_003083769.1 LysR family transcriptional regulator -
DZ927_RS00720 152019..152300 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
DZ927_RS00725 152297..152524 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
DZ927_RS00730 152700..153323 - 624 WP_003137011.1 hypothetical protein -
DZ927_RS00735 153424..153924 + 501 WP_003101228.1 LEA type 2 family protein -
DZ927_RS00740 153996..154337 + 342 WP_003101229.1 alkylphosphonate utilization protein -
DZ927_RS00745 154419..155846 - 1428 WP_003083784.1 GABA permease -
DZ927_RS00750 156015..157508 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T123737 WP_003083773.1 NZ_CP039293:c152300-152019 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T123737 NZ_CP039293:c152300-152019 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCCCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCTTTTCGGGTAAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT123737 WP_003083775.1 NZ_CP039293:c152524-152297 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT123737 NZ_CP039293:c152524-152297 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCTGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCGTATCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References