Detailed information of TA system TA123737

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 152019..152524
• Replicon: chromosome
• Accession: NZ_CP039293
• Organism: Pseudomonas aeruginosa strain PABL048

Toxin (Protein)

• Gene name: parE
• Uniprot ID: V6A7K8
• Locus tag: DZ927_RS00720
• Protein ID: WP_003083773.1
• Coordinates: 152019..152300 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1C7BDS9
• Locus tag: DZ927_RS00725
• Protein ID: WP_003083775.1
• Coordinates: 152297..152524 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DZ927_RS00695	147270..148619	+	1350	WP_003137006.1	C4-dicarboxylate transporter DctA	-
DZ927_RS00700	148668..149354	+	687	WP_003083762.1	FadR family transcriptional regulator	-
DZ927_RS00705	149455..150189	+	735	WP_003110658.1	GntR family transcriptional regulator	-
DZ927_RS00710	150393..150779	+	387	WP_003083767.1	aegerolysin family protein	-
DZ927_RS00715	150811..151719	-	909	WP_003083769.1	LysR family transcriptional regulator	-
DZ927_RS00720	152019..152300	-	282	WP_003083773.1	type II toxin-antitoxin system toxin ParE	Toxin
DZ927_RS00725	152297..152524	-	228	WP_003083775.1	CopG family ribbon-helix-helix protein	Antitoxin
DZ927_RS00730	152700..153323	-	624	WP_003137011.1	hypothetical protein	-
DZ927_RS00735	153424..153924	+	501	WP_003101228.1	LEA type 2 family protein	-
DZ927_RS00740	153996..154337	+	342	WP_003101229.1	alkylphosphonate utilization protein	-
DZ927_RS00745	154419..155846	-	1428	WP_003083784.1	GABA permease	-
DZ927_RS00750	156015..157508	-	1494	WP_003101230.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10462.19 Da
• Isoelectric Point: 10.0435

>T123737 WP_003083773.1 NZ_CP039293:c152300-152019 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Nucleotide

• Length: 282 bp

>T123737 NZ_CP039293:c152300-152019 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCCCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCTTTTCGGGTAAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8556.58 Da
• Isoelectric Point: 5.5740

>AT123737 WP_003083775.1 NZ_CP039293:c152524-152297 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT123737 NZ_CP039293:c152524-152297 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCTGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCGTATCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Structures

Toxin

• PDB: 6XRW

Antitoxin

• AlphaFold DB: A0A1C7BDS9