Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpIK/MazF(toxin)
Location 3113420..3113988 Replicon chromosome
Accession NZ_CP039292
Organism Actinomyces procaprae strain dk561

Toxin (Protein)


Gene name chpK Uniprot ID -
Locus tag E4J16_RS12725 Protein ID WP_136314201.1
Coordinates 3113641..3113988 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name chpI Uniprot ID -
Locus tag E4J16_RS12720 Protein ID WP_136314200.1
Coordinates 3113420..3113653 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4J16_RS12700 3109597..3109935 + 339 WP_136314197.1 hypothetical protein -
E4J16_RS12705 3110216..3110557 - 342 WP_136314198.1 transcriptional regulator -
E4J16_RS15195 3110616..3110774 + 159 WP_168709512.1 hypothetical protein -
E4J16_RS12710 3110816..3111103 - 288 WP_092606642.1 CRISPR-associated endonuclease Cas2 -
E4J16_RS12715 3111094..3112974 - 1881 WP_168709513.1 CRISPR-associated endonuclease Cas1 -
E4J16_RS12720 3113420..3113653 + 234 WP_136314200.1 hypothetical protein Antitoxin
E4J16_RS12725 3113641..3113988 + 348 WP_136314201.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
E4J16_RS12730 3116682..3117494 + 813 WP_136314707.1 CRISPR system precrRNA processing endoribonuclease RAMP protein Cas6 -
E4J16_RS12735 3117562..3118116 - 555 WP_136193950.1 hypoxanthine phosphoribosyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-115)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12486.45 Da        Isoelectric Point: 8.0236

>T123736 WP_136314201.1 NZ_CP039292:3113641-3113988 [Actinomyces procaprae]
MAVVARGEVWWLDFGDPIGSEPGYLRPALIVSSDRFNRSRIATVIVSAITSNLRLAAAPGNVELERGEAGLPKQCVVNVS
QTLVVDRSRLNNRIGAVPMHILARVDDGLRLVLDL

Download         Length: 348 bp

>T123736 NZ_CP039292:3113641-3113988 [Actinomyces procaprae]
ATGGCCGTGGTAGCTCGGGGTGAGGTCTGGTGGCTCGACTTCGGCGACCCCATCGGCTCGGAACCCGGCTACCTCAGGCC
CGCCCTGATCGTCTCCTCGGACCGGTTCAACCGATCCCGTATAGCCACCGTCATCGTGTCAGCCATAACCAGCAACCTGC
GCCTGGCAGCGGCGCCGGGCAACGTCGAGCTGGAGCGCGGTGAGGCGGGTCTGCCCAAGCAGTGCGTCGTCAATGTCTCG
CAAACTCTTGTCGTTGACCGCTCCAGGTTGAACAACCGCATCGGCGCTGTCCCCATGCACATTCTCGCCCGCGTGGACGA
TGGACTTCGACTGGTGCTGGACCTTTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8647.71 Da        Isoelectric Point: 4.5183

>AT123736 WP_136314200.1 NZ_CP039292:3113420-3113653 [Actinomyces procaprae]
VKTAVSIPDPVFQEAEEVARRLGWSRSQLYTKAVHDLIVRYSDDPVTEALNALEDVESAQTPLTPARRLIESGAWPW

Download         Length: 234 bp

>AT123736 NZ_CP039292:3113420-3113653 [Actinomyces procaprae]
GTGAAGACAGCGGTATCCATTCCAGACCCGGTATTCCAGGAGGCCGAGGAAGTTGCGCGGCGCCTCGGCTGGAGCCGTTC
GCAGCTGTACACGAAGGCCGTCCACGACCTGATTGTTCGCTACAGCGATGATCCTGTGACTGAAGCGCTCAACGCCCTCG
AAGATGTCGAGTCGGCACAGACGCCGTTGACACCGGCCAGGAGACTCATCGAGTCGGGGGCATGGCCGTGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References