Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 690449..691026 Replicon chromosome
Accession NZ_CP039291
Organism Cellulomonas shaoxiangyii strain Z28

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag E5225_RS03160 Protein ID WP_135972620.1
Coordinates 690676..691026 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag E5225_RS03155 Protein ID WP_135972619.1
Coordinates 690449..690679 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E5225_RS03125 687389..688315 + 927 WP_208012482.1 hypothetical protein -
E5225_RS03130 688379..688693 - 315 WP_208012483.1 rhodanese-like domain-containing protein -
E5225_RS03135 688717..688980 - 264 WP_135972615.1 hypothetical protein -
E5225_RS03140 688977..689420 - 444 WP_208012484.1 hypothetical protein -
E5225_RS03145 689442..689867 - 426 WP_135972617.1 MarR family winged helix-turn-helix transcriptional regulator -
E5225_RS03150 689877..690287 - 411 WP_135972618.1 TIGR03618 family F420-dependent PPOX class oxidoreductase -
E5225_RS03155 690449..690679 + 231 WP_135972619.1 ribbon-helix-helix domain-containing protein Antitoxin
E5225_RS03160 690676..691026 + 351 WP_135972620.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
E5225_RS03165 691071..692471 - 1401 WP_135972621.1 TrkH family potassium uptake protein -
E5225_RS03170 692755..693798 + 1044 Protein_626 DUF4118 domain-containing protein -
E5225_RS03175 693795..694469 + 675 WP_135972622.1 response regulator -
E5225_RS03185 694805..695437 - 633 WP_135972623.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12452.27 Da        Isoelectric Point: 8.9115

>T123734 WP_135972620.1 NZ_CP039291:690676-691026 [Cellulomonas shaoxiangyii]
VSRRGEVWLVDLEPARGTEADKTRPAVIVGNQAAVTAAFASGRGVVTVVPVTSNVTRVLPFQTELPAGETGLEKDSKAQA
EQVRSVDVARLVEPVGSLSPRLMRELERALRLHLSL

Download         Length: 351 bp

>T123734 NZ_CP039291:690676-691026 [Cellulomonas shaoxiangyii]
GTGAGCCGGCGCGGCGAGGTGTGGCTCGTCGACCTGGAGCCGGCACGCGGCACGGAGGCGGACAAGACGCGGCCTGCGGT
GATCGTCGGCAACCAGGCCGCCGTGACGGCGGCGTTCGCCTCCGGGAGGGGAGTCGTCACGGTCGTCCCCGTGACGTCGA
ACGTGACCCGGGTCCTGCCGTTCCAGACTGAGCTCCCGGCGGGGGAGACCGGCCTCGAGAAGGACTCGAAGGCGCAGGCC
GAGCAGGTGCGCTCCGTCGACGTCGCGCGCCTCGTGGAGCCGGTCGGGTCGCTCTCGCCGAGGCTGATGCGCGAGCTCGA
GCGCGCGCTGCGCCTGCACCTCTCCCTCTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8213.88 Da        Isoelectric Point: 4.4702

>AT123734 WP_135972619.1 NZ_CP039291:690449-690679 [Cellulomonas shaoxiangyii]
MKLSVSLPEDDVATLDRYVQQHPGATRSSAVQDAVRLLRDRTLQEQYGEAFAEWTASADASAWDSTSGDGRRGGSA

Download         Length: 231 bp

>AT123734 NZ_CP039291:690449-690679 [Cellulomonas shaoxiangyii]
ATGAAACTGAGCGTGAGTCTCCCCGAGGACGACGTGGCGACGCTCGACCGCTACGTCCAGCAGCACCCCGGCGCGACGCG
GTCCTCGGCCGTGCAGGACGCGGTGCGCCTGCTGCGCGACCGCACCCTGCAGGAGCAGTACGGCGAGGCGTTCGCCGAGT
GGACGGCCTCCGCAGATGCCTCGGCCTGGGACTCCACGTCCGGCGACGGCCGGCGCGGCGGCTCTGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References