Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 605901..606580 Replicon chromosome
Accession NZ_CP039291
Organism Cellulomonas shaoxiangyii strain Z28

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag E5225_RS02730 Protein ID WP_135972957.1
Coordinates 605901..606338 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag E5225_RS02735 Protein ID WP_135972958.1
Coordinates 606335..606580 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E5225_RS02710 602463..602945 - 483 WP_135972953.1 2'-5' RNA ligase family protein -
E5225_RS02715 603081..603863 + 783 WP_135972954.1 GNAT family N-acetyltransferase -
E5225_RS02720 604037..605296 - 1260 WP_208012499.1 O-succinylhomoserine sulfhydrylase -
E5225_RS02725 605293..605736 - 444 WP_135972956.1 rhodanese-like domain-containing protein -
E5225_RS02730 605901..606338 - 438 WP_135972957.1 type II toxin-antitoxin system VapC family toxin Toxin
E5225_RS02735 606335..606580 - 246 WP_135972958.1 ribbon-helix-helix protein, CopG family Antitoxin
E5225_RS02740 606912..608096 - 1185 WP_135972959.1 hypothetical protein -
E5225_RS02745 608842..609813 - 972 WP_135972960.1 hypothetical protein -
E5225_RS02750 610385..610588 + 204 WP_135972995.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(2-139)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-40)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15699.82 Da        Isoelectric Point: 6.7561

>T123733 WP_135972957.1 NZ_CP039291:c606338-605901 [Cellulomonas shaoxiangyii]
VILPDVNVLVGAFRADAPRHDALRAWLEEAVAGPETLGVTDAVLGGTVRVLTHPRVFARPTPLAEALTQVEALRSHPDVV
RVAPGARHWDLVTRLCRDADARGNLVADAQHAAVAVEHGATWVSQDRDFARFPGLRWRPAVTDVT

Download         Length: 438 bp

>T123733 NZ_CP039291:c606338-605901 [Cellulomonas shaoxiangyii]
GTGATCCTGCCGGACGTGAACGTGCTCGTGGGCGCGTTCCGCGCGGACGCCCCGCGCCACGACGCCCTGCGTGCCTGGCT
GGAGGAGGCCGTGGCGGGCCCGGAGACCCTCGGCGTGACCGACGCGGTGCTCGGGGGGACGGTGCGCGTCCTGACCCATC
CGCGGGTCTTCGCCCGGCCCACCCCGCTCGCCGAGGCGCTCACCCAGGTGGAGGCGCTGCGCAGCCACCCGGACGTCGTC
CGCGTCGCGCCGGGCGCGCGCCACTGGGACCTGGTCACCCGGCTGTGCCGCGACGCGGACGCGCGCGGGAACCTCGTGGC
GGACGCCCAGCACGCCGCCGTCGCGGTCGAGCACGGCGCCACGTGGGTGTCGCAGGACCGCGACTTCGCCCGGTTCCCCG
GGCTGCGCTGGCGGCCGGCGGTCACCGACGTGACGTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8547.58 Da        Isoelectric Point: 4.4883

>AT123733 WP_135972958.1 NZ_CP039291:c606580-606335 [Cellulomonas shaoxiangyii]
MRTTLNLPDDLYREVRTTAAATGRTVTSVVEEALRDALARYRAEQAGARTPFVVTPCGSGGLAPGVDLDDSAALVDVLEG
R

Download         Length: 246 bp

>AT123733 NZ_CP039291:c606580-606335 [Cellulomonas shaoxiangyii]
ATGCGCACGACGCTGAACCTGCCGGACGACCTCTACCGCGAGGTGCGGACGACCGCGGCGGCGACCGGCCGCACGGTGAC
CTCGGTGGTCGAGGAGGCGCTGCGTGACGCGTTGGCCCGGTACCGCGCGGAGCAGGCCGGCGCCCGCACCCCGTTCGTGG
TGACGCCGTGCGGATCGGGCGGGCTCGCGCCCGGCGTCGACCTCGACGACTCCGCCGCGCTCGTGGACGTGCTGGAGGGC
CGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References