Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 179194..179786 Replicon chromosome
Accession NZ_CP039291
Organism Cellulomonas shaoxiangyii strain Z28

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag E5225_RS00865 Protein ID WP_208012457.1
Coordinates 179454..179786 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag E5225_RS00860 Protein ID WP_166435891.1
Coordinates 179194..179418 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E5225_RS00835 174467..175150 + 684 WP_135972298.1 hypothetical protein -
E5225_RS00840 175301..175477 + 177 Protein_165 antitoxin -
E5225_RS00845 175752..177074 - 1323 WP_135972329.1 MFS transporter -
E5225_RS17375 177478..178206 + 729 WP_166435892.1 DUF998 domain-containing protein -
E5225_RS00855 178203..179165 + 963 WP_135972296.1 LLM class flavin-dependent oxidoreductase -
E5225_RS00860 179194..179418 + 225 WP_166435891.1 ribbon-helix-helix protein, CopG family Antitoxin
E5225_RS00865 179454..179786 + 333 WP_208012457.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
E5225_RS00870 180013..182250 + 2238 WP_135972294.1 glycoside hydrolase family 92 protein -
E5225_RS00875 182430..183719 + 1290 WP_135972327.1 glycosyltransferase -
E5225_RS00880 183821..184054 + 234 WP_135972293.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
E5225_RS00885 184051..184422 + 372 WP_135972292.1 type II toxin-antitoxin system VapC family toxin -
E5225_RS00890 184463..184708 - 246 WP_135972291.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12180.88 Da        Isoelectric Point: 10.6803

>T123732 WP_208012457.1 NZ_CP039291:179454-179786 [Cellulomonas shaoxiangyii]
VVWRGTVAWADLTPGRGREQDGHRPVLVVSSRQYLETVTTVLVVLPVTSTDRGWSNHVPLRGATGLGRPSWAMTEQPRTI
ARERLSRVVGVVDDATLRDVDGWLRDLLGL

Download         Length: 333 bp

>T123732 NZ_CP039291:179454-179786 [Cellulomonas shaoxiangyii]
GTGGTGTGGCGCGGCACGGTGGCCTGGGCCGACCTCACGCCCGGACGCGGGCGCGAGCAGGACGGTCACCGGCCGGTGCT
CGTCGTGAGCTCCCGTCAGTACCTCGAGACGGTGACGACCGTGCTGGTGGTCCTGCCCGTGACGTCGACGGACCGCGGCT
GGTCGAACCACGTCCCGCTCCGCGGCGCCACGGGGCTGGGGCGTCCGTCCTGGGCGATGACCGAGCAGCCGCGGACCATC
GCGCGCGAGCGCCTGTCCCGCGTCGTGGGGGTGGTCGACGACGCGACGCTGCGCGACGTGGACGGCTGGCTGCGCGACCT
GCTGGGCCTCTGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8213.11 Da        Isoelectric Point: 4.4091

>AT123732 WP_166435891.1 NZ_CP039291:179194-179418 [Cellulomonas shaoxiangyii]
VTATTIKLDSDLRDRLNAAARERGVTTGSFVEALFEGWLREQRFAALREEMARTPPDAAYAADADAWDVTLADR

Download         Length: 225 bp

>AT123732 NZ_CP039291:179194-179418 [Cellulomonas shaoxiangyii]
GTGACCGCCACGACGATCAAGCTGGACTCGGACCTCCGCGACCGCCTCAACGCGGCCGCGCGCGAGCGCGGTGTCACGAC
GGGGTCCTTCGTCGAGGCGCTGTTCGAGGGCTGGCTCAGGGAGCAGCGGTTCGCCGCGCTGCGCGAGGAGATGGCGCGCA
CACCCCCGGACGCCGCGTACGCCGCGGACGCGGACGCCTGGGACGTGACCCTGGCCGACCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References