Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 2798716..2799259 Replicon chromosome
Accession NZ_CP039288
Organism Cupriavidus necator H16

Toxin (Protein)


Gene name relE Uniprot ID Q0JYB8
Locus tag E6A55_RS31680 Protein ID WP_011617903.1
Coordinates 2798716..2799006 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID R7XLV2
Locus tag E6A55_RS31685 Protein ID WP_010810750.1
Coordinates 2798993..2799259 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E6A55_RS31670 2795312..2796847 + 1536 WP_010810746.1 amino acid permease -
E6A55_RS31675 2796928..2798604 + 1677 WP_037024735.1 amidohydrolase family protein -
E6A55_RS31680 2798716..2799006 - 291 WP_011617903.1 type II toxin-antitoxin system YafQ family toxin Toxin
E6A55_RS31685 2798993..2799259 - 267 WP_010810750.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
E6A55_RS31690 2799541..2801703 + 2163 WP_011617904.1 TonB-dependent receptor -
E6A55_RS31695 2801760..2802737 - 978 WP_010810752.1 tripartite tricarboxylate transporter substrate binding protein -
E6A55_RS31700 2802821..2803636 - 816 WP_011617905.1 enoyl-CoA hydratase/isomerase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2751904..2799259 47355


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-94)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-83)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11214.01 Da        Isoelectric Point: 10.0499

>T123731 WP_011617903.1 NZ_CP039288:c2799006-2798716 [Cupriavidus necator H16]
MRTIERTTQFKRDYKRELKGPFKALLQSPAGDWFAILTALASDMSLPDKFRDHALGGQWKDFRDCHVRPDLLLIYRKPDP
WTLQLVRLGSHSELAM

Download         Length: 291 bp

>T123731 NZ_CP039288:c2799006-2798716 [Cupriavidus necator H16]
ATGAGGACGATTGAACGGACGACCCAATTCAAGCGCGATTACAAGCGCGAACTCAAAGGGCCGTTCAAGGCGCTGCTGCA
AAGCCCGGCTGGTGACTGGTTTGCAATCCTGACTGCCTTGGCGAGTGACATGTCGCTGCCGGACAAATTTCGCGACCATG
CGCTTGGCGGCCAGTGGAAGGACTTCCGGGATTGCCATGTTCGGCCAGACCTTTTGCTGATCTATCGGAAGCCAGACCCT
TGGACACTGCAACTTGTCCGGCTTGGGTCGCATAGCGAGCTGGCCATGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9489.96 Da        Isoelectric Point: 4.4692

>AT123731 WP_010810750.1 NZ_CP039288:c2799259-2798993 [Cupriavidus necator H16]
MSASTFVRARIDVEIKEEAAIVLEAMGLTVSDAVRMLLTRVAREKALPVELMTPNPATIASLKEARAGGLRKFGSVSDLM
ADLNDEDD

Download         Length: 267 bp

>AT123731 NZ_CP039288:c2799259-2798993 [Cupriavidus necator H16]
ATGTCCGCTTCGACCTTTGTCCGAGCCCGTATCGACGTTGAAATCAAGGAAGAGGCCGCGATCGTTCTGGAAGCGATGGG
ACTGACGGTTTCAGACGCCGTGCGCATGCTTTTGACGCGCGTGGCACGTGAAAAGGCATTGCCTGTGGAACTGATGACTC
CCAATCCAGCAACCATTGCGTCGCTAAAAGAGGCGCGGGCCGGTGGCCTCCGCAAGTTCGGGTCGGTGAGCGACCTGATG
GCGGATCTCAACGATGAGGACGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T4G011

Antitoxin

Source ID Structure
AlphaFold DB A0A7T4FZW4

References