123727

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ParST/RES-TIGR02293
Location 1420297..1421282 Replicon chromosome
Accession NZ_CP039288
Organism Cupriavidus necator H16

Toxin (Protein)


Gene name ParT Uniprot ID Q0K1S1
Locus tag E6A55_RS25615 Protein ID WP_011617110.1
Coordinates 1420809..1421282 (+) Length 158 a.a.

Antitoxin (Protein)


Gene name ParS Uniprot ID Q0K1S2
Locus tag E6A55_RS25610 Protein ID WP_011617109.1
Coordinates 1420297..1420812 (+) Length 172 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E6A55_RS25580 1415737..1416381 + 645 WP_010809399.1 TetR/AcrR family transcriptional regulator -
E6A55_RS25585 1416697..1417008 + 312 WP_011617106.1 hypothetical protein -
E6A55_RS25590 1417086..1417268 + 183 WP_010809397.1 hypothetical protein -
E6A55_RS25595 1417321..1417746 - 426 WP_035823937.1 hypothetical protein -
E6A55_RS25600 1417993..1419120 - 1128 WP_041688081.1 site-specific integrase -
E6A55_RS25605 1419234..1420199 + 966 WP_011617108.1 DNA-binding protein -
E6A55_RS25610 1420297..1420812 + 516 WP_011617109.1 DUF2384 domain-containing protein Antitoxin
E6A55_RS25615 1420809..1421282 + 474 WP_011617110.1 RES family NAD+ phosphorylase Toxin
E6A55_RS25620 1421286..1422863 - 1578 WP_011617111.1 fatty acid--CoA ligase -
E6A55_RS25625 1423096..1425366 + 2271 WP_041688083.1 ATP-dependent DNA helicase -
E6A55_RS25630 1425491..1425814 + 324 WP_010809389.1 thioredoxin family protein -
E6A55_RS25635 1425832..1426263 - 432 WP_010809388.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(4-152)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(44-105)


Sequences

Toxin        


Download         Length: 158 a.a.        Molecular weight: 16706.95 Da        Isoelectric Point: 6.2220

>T123727 WP_011617110.1 NZ_CP039288:1420809-1421282 [Cupriavidus necator H16]
VRPAWRIATDTPDYTADDASGAGAKATGGRWNRQGTPLIYAASSIALACLETLVHLGSGGLPLNRYLVRIDIPDELWAAA
QKLSVDTAPVGWDAIPAGKTSLDTGEAWTAGGTSALLLVPSIVIPEEHNVLVNPAHPDAARLAYVKVRRWQYDARLV

Download         Length: 474 bp

>T123727 NZ_CP039288:1420809-1421282 [Cupriavidus necator H16]
GTGAGGCCAGCCTGGCGGATCGCGACCGACACCCCAGACTACACCGCCGACGACGCCAGCGGCGCCGGCGCCAAGGCCAC
CGGCGGGCGCTGGAACCGGCAGGGCACGCCCTTGATTTATGCGGCGTCCAGCATCGCGCTGGCTTGCCTGGAAACGCTGG
TCCACCTGGGTTCAGGCGGGCTGCCGCTGAACCGCTACCTGGTCCGGATCGACATCCCCGACGAGCTATGGGCGGCTGCG
CAGAAACTGAGCGTCGACACCGCCCCCGTAGGCTGGGATGCCATTCCCGCCGGAAAGACCAGCCTCGACACCGGCGAAGC
CTGGACCGCCGGGGGCACCAGCGCCTTGCTGCTGGTGCCTTCCATCGTCATCCCTGAAGAGCACAACGTGCTGGTCAACC
CGGCGCACCCCGACGCCGCGCGGCTGGCTTACGTCAAGGTCCGCCGCTGGCAGTACGACGCGCGCCTGGTCTGA

Antitoxin


Download         Length: 172 a.a.        Molecular weight: 18518.17 Da        Isoelectric Point: 9.5015

>AT123727 WP_011617109.1 NZ_CP039288:1420297-1420812 [Cupriavidus necator H16]
MPLMLTPKGRYPLAHERPAPPELGVNNYVAVYEASLSTQGAMSIIRAIREGVPASDLNRLAESMGTTKEQLIKTLDLPRA
TVDRKARAHQNLSSEQSERVLGMARLVGQVQALVESSGDPRGFSAAQWVAQWLEQPSPALGGRRPAELMDTLAGQRIVSD
LVARMQSGAYA

Download         Length: 516 bp

>AT123727 NZ_CP039288:1420297-1420812 [Cupriavidus necator H16]
ATGCCGCTCATGCTCACTCCCAAAGGCCGCTATCCGCTGGCTCATGAACGCCCGGCTCCGCCCGAGCTGGGCGTCAACAA
CTACGTCGCCGTCTATGAGGCCAGCCTGTCGACGCAAGGCGCCATGTCGATCATCCGCGCGATTCGTGAAGGTGTGCCGG
CTTCAGACCTGAACCGCCTGGCCGAATCCATGGGCACCACCAAGGAGCAGCTGATCAAGACACTGGACTTGCCCCGCGCC
ACCGTGGACCGCAAGGCACGGGCGCACCAGAACCTGTCGAGCGAGCAGAGCGAGCGTGTGCTGGGCATGGCGCGGCTGGT
CGGGCAGGTCCAGGCGCTGGTGGAAAGCTCGGGCGATCCGCGCGGTTTCAGCGCGGCGCAGTGGGTGGCGCAGTGGCTGG
AGCAGCCTTCGCCGGCGCTGGGCGGGCGCCGCCCCGCTGAGCTGATGGATACGCTCGCCGGCCAGCGTATCGTTTCCGAC
CTGGTGGCCAGGATGCAGAGCGGGGCGTACGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T4KPF4

Antitoxin

Source ID Structure
AlphaFold DB A0A7T4KN77

References