Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 3163577..3164216 Replicon chromosome
Accession NZ_CP039287
Organism Cupriavidus necator H16

Toxin (Protein)


Gene name vapC Uniprot ID Q0K7L6
Locus tag E6A55_RS14945 Protein ID WP_011615916.1
Coordinates 3163800..3164216 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID R7XDA2
Locus tag E6A55_RS14940 Protein ID WP_010813840.1
Coordinates 3163577..3163813 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E6A55_RS14925 3159195..3160613 + 1419 WP_010813837.1 argininosuccinate lyase -
E6A55_RS14930 3160903..3161505 + 603 WP_011615914.1 TRAP transporter small permease subunit -
E6A55_RS14935 3161518..3163233 + 1716 WP_136227787.1 TRAP transporter large permease subunit -
E6A55_RS14940 3163577..3163813 + 237 WP_010813840.1 plasmid stability protein StbC Antitoxin
E6A55_RS14945 3163800..3164216 + 417 WP_011615916.1 type II toxin-antitoxin system VapC family toxin Toxin
E6A55_RS14950 3164285..3166558 - 2274 WP_011615917.1 arginine/lysine/ornithine decarboxylase -
E6A55_RS14955 3166709..3167275 - 567 WP_010813843.1 dCTP deaminase -
E6A55_RS14960 3167372..3168202 - 831 WP_010813844.1 formate dehydrogenase accessory sulfurtransferase FdhD -
E6A55_RS14965 3168266..3168655 - 390 WP_011615918.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15333.56 Da        Isoelectric Point: 6.7296

>T123725 WP_011615916.1 NZ_CP039287:3163800-3164216 [Cupriavidus necator H16]
VYLIDTNVISETRKRERANPGVRAFFRQAAREGAALYLSALTVGELQRGVALIRHRGDTAQAELLEQWLATVLEDFGRLV
LPVDADVAQVWGQLRAPRPEHALDKFIAATALIHDLTIVTRNVEDFRGTGAMLLNPFT

Download         Length: 417 bp

>T123725 NZ_CP039287:3163800-3164216 [Cupriavidus necator H16]
GTGTATTTGATTGATACCAACGTCATCAGCGAAACGCGCAAGCGCGAGCGCGCCAACCCCGGCGTGCGCGCGTTCTTCCG
GCAGGCGGCGCGGGAAGGTGCCGCGCTCTACCTGTCGGCGCTGACCGTGGGCGAGCTCCAGCGTGGCGTAGCGCTGATCC
GCCATCGCGGCGATACGGCGCAGGCCGAGCTGCTGGAGCAATGGCTGGCGACCGTGCTGGAGGATTTTGGCCGGCTGGTG
TTGCCGGTCGATGCCGACGTCGCCCAGGTCTGGGGCCAGCTGCGCGCGCCGCGGCCTGAGCACGCGCTGGACAAGTTCAT
TGCCGCCACCGCGCTGATCCATGACCTGACCATTGTCACGCGCAATGTTGAGGATTTCCGCGGCACGGGCGCGATGCTGC
TGAATCCGTTCACCTAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8508.59 Da        Isoelectric Point: 5.8236

>AT123725 WP_010813840.1 NZ_CP039287:3163577-3163813 [Cupriavidus necator H16]
MATLLVRGIDESLVQRLRERAVANGRSAEAEHRAILAQALGGTRRRSLAEVLASIPDVGQDADFERIQNPGEAPRVFD

Download         Length: 237 bp

>AT123725 NZ_CP039287:3163577-3163813 [Cupriavidus necator H16]
ATGGCAACACTACTCGTTCGTGGCATCGATGAATCCCTGGTCCAGCGCCTGCGCGAGCGGGCCGTCGCCAACGGCCGCAG
CGCCGAGGCCGAGCACCGCGCCATCCTGGCGCAGGCGCTGGGCGGCACGCGCCGGCGCAGCCTGGCCGAGGTGCTGGCCA
GCATCCCGGACGTCGGGCAAGACGCCGACTTCGAGCGGATCCAGAATCCAGGCGAGGCGCCGCGTGTATTTGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T4KI19

Antitoxin

Source ID Structure
AlphaFold DB A0A7T4KI67

References