Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazE-MazF
Location 68652..69217 Replicon plasmid pLiSL3
Accession NZ_CP039286
Organism Leptospira interrogans strain FMAS_AW1

Toxin (Protein)


Gene name mazF Uniprot ID A0A0F6H5X2
Locus tag E4414_RS22590 Protein ID WP_000648189.1
Coordinates 68652..68900 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A0C5XAD8
Locus tag E4414_RS22595 Protein ID WP_000237066.1
Coordinates 68894..69217 (+) Length 108 a.a.

Genomic Context

E4414_RS22565E4414_RS22570E4414_RS22575E4414_RS22580E4414_RS22585E4414_RS22590E4414_RS22595E4414_RS22600E4414_RS22605E4414_RS22630E4414_RS22560E4414_RS23125E4414_RS22625E4414_RS22635
Location: 65010..65513 (504 bp)
Type: Others
Protein ID: WP_000614121.1
Location: 65645..66133 (489 bp)
Type: Others
Protein ID: WP_002131542.1
Location: 66253..66498 (246 bp)
Type: Others
Protein ID: WP_000695324.1
Location: 67383..67688 (306 bp)
Type: Others
Protein ID: WP_000844596.1
Location: 67661..68347 (687 bp)
Type: Others
Protein ID: WP_082278913.1
Location: 68652..68900 (249 bp)
Type: Toxin
Protein ID: WP_000648189.1
Location: 68894..69217 (324 bp)
Type: Antitoxin
Protein ID: WP_000237066.1
Location: 69340..69510 (171 bp)
Type: Others
Protein ID: WP_002106501.1
Location: 69669..70430 (762 bp)
Type: Others
Protein ID: Protein_70
Location: 72427..73500 (1074 bp)
Type: Others
Protein ID: WP_162303305.1
Location: 64269..64763 (495 bp)
Type: Others
Protein ID: WP_017858174.1
Location: 69574..69753 (180 bp)
Type: Others
Protein ID: WP_000536132.1
Location: 71299..72177 (879 bp)
Type: Others
Protein ID: Protein_71
Location: 73539..73857 (319 bp)
Type: Others
Protein ID: Protein_73
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
E4414_RS2256064269..64763-495WP_017858174.1hypothetical protein-
E4414_RS2256565010..65513+504WP_000614121.1hypothetical protein-
E4414_RS2257065645..66133+489WP_002131542.1DUF4942 domain-containing protein-
E4414_RS2257566253..66498+246WP_000695324.1hypothetical protein-
E4414_RS2258067383..67688+306WP_000844596.1hypothetical protein-
E4414_RS2258567661..68347+687WP_082278913.1restriction endonuclease-
E4414_RS2259068652..68900+249WP_000648189.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinToxin
E4414_RS2259568894..69217+324WP_000237066.1type II toxin-antitoxin system PemK/MazF family toxinAntitoxin
E4414_RS2260069340..69510+171WP_002106501.1hypothetical protein-
E4414_RS2312569574..69753-180WP_000536132.1hypothetical protein-
E4414_RS2260569669..70430+762Protein_70hypothetical protein-
E4414_RS2262571299..72177-879Protein_71galactose oxidase-
E4414_RS2263072427..73500+1074WP_162303305.1IS110 family transposase-
E4414_RS2263573539..73857-319Protein_73galactose oxidase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..8426784267
-flankIS/Tn--72427..735001073


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

SpoVT-AbrB domain

(6-49)

Antitoxin

mRNA interferase PemK-like

(2-105)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9507.04 Da        Isoelectric Point: 5.1749

>T123721 WP_000648189.1 NZ_CP039286:68652-68900 [Leptospira interrogans]
MKASVVKIGNSKGIRIPKAVLEECHIEEEVDLLIDNNKLIIVPLKSKPREGWEKQFKTMSSNKDDKLFIPDSIDLLDKDW
EW

Download         Length: 249 bp

>T123721 NZ_CP039286:68652-68900 [Leptospira interrogans]
ATGAAGGCTTCAGTCGTAAAAATAGGCAATTCCAAAGGTATTCGAATTCCCAAGGCAGTCTTAGAAGAATGTCATATTGA
AGAAGAAGTAGATTTACTAATCGATAATAACAAATTAATTATTGTACCTCTAAAATCGAAACCAAGAGAAGGGTGGGAAA
AACAATTTAAAACAATGTCATCTAATAAAGATGATAAATTATTTATTCCTGATTCAATAGATTTATTAGACAAGGATTGG
GAATGGTGA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12168.59 Da        Isoelectric Point: 10.5161

>AT123721 WP_000237066.1 NZ_CP039286:68894-69217 [Leptospira interrogans]
MVISQYEVYLINLDPTVGHEIKKSRPCAIISPNEMNKTIGTIIIAPMTTKSRSYPTRVELTFQGKKGWIVLDQIRAVDKT
RLVKKLGKIDPKTVNKMKLVIKEMLVD

Download         Length: 324 bp

>AT123721 NZ_CP039286:68894-69217 [Leptospira interrogans]
ATGGTGATTTCTCAATACGAAGTATATCTAATAAATTTAGATCCAACGGTTGGACATGAGATAAAAAAATCAAGACCTTG
TGCAATAATCTCACCCAATGAAATGAATAAAACGATTGGAACAATTATTATTGCACCAATGACTACAAAATCTCGATCAT
ATCCGACAAGAGTTGAATTAACCTTTCAAGGAAAGAAGGGTTGGATTGTGTTAGATCAGATTCGAGCTGTTGATAAAACA
CGTCTGGTAAAGAAGTTAGGAAAAATAGATCCCAAAACAGTTAATAAAATGAAACTGGTAATAAAGGAAATGTTGGTTGA
TTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0F6H5X2

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0C5XAD8

References