Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 39001..39572 Replicon plasmid pLiSL2
Accession NZ_CP039285
Organism Leptospira interrogans strain FMAS_AW1

Toxin (Protein)


Gene name mazF Uniprot ID Q8F5A3
Locus tag E4414_RS21715 Protein ID WP_000240418.1
Coordinates 39001..39342 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID M6U553
Locus tag E4414_RS21720 Protein ID WP_000443825.1
Coordinates 39336..39572 (-) Length 79 a.a.

Genomic Context

E4414_RS23450E4414_RS21695E4414_RS21700E4414_RS21705E4414_RS21710E4414_RS21675E4414_RS21680E4414_RS21685E4414_RS21690E4414_RS21715E4414_RS21720E4414_RS21725E4414_RS21730E4414_RS21735E4414_RS21740E4414_RS21745E4414_RS21755E4414_RS21760E4414_RS21765E4414_RS21770
Location: 37045..37191 (147 bp)
Type: Others
Protein ID: WP_167493406.1
Location: 37154..37879 (726 bp)
Type: Others
Protein ID: WP_000414903.1
Location: 37882..38223 (342 bp)
Type: Others
Protein ID: WP_000727287.1
Location: 38284..38550 (267 bp)
Type: Others
Protein ID: WP_000844450.1
Location: 38550..38933 (384 bp)
Type: Others
Protein ID: WP_000617796.1
Location: 34827..35438 (612 bp)
Type: Others
Protein ID: WP_017857624.1
Location: 35546..36007 (462 bp)
Type: Others
Protein ID: WP_000811790.1
Location: 36530..36730 (201 bp)
Type: Others
Protein ID: WP_017857623.1
Location: 36735..36896 (162 bp)
Type: Others
Protein ID: Protein_33
Location: 39001..39342 (342 bp)
Type: Toxin
Protein ID: WP_000240418.1
Location: 39336..39572 (237 bp)
Type: Antitoxin
Protein ID: WP_000443825.1
Location: 39912..40919 (1008 bp)
Type: Others
Protein ID: WP_000628975.1
Location: 41255..41443 (189 bp)
Type: Others
Protein ID: WP_000425065.1
Location: 41613..41828 (216 bp)
Type: Others
Protein ID: WP_017857593.1
Location: 41818..42258 (441 bp)
Type: Others
Protein ID: WP_001289702.1
Location: 42255..42488 (234 bp)
Type: Others
Protein ID: WP_000416314.1
Location: 42693..43127 (435 bp)
Type: Others
Protein ID: WP_061226524.1
Location: 43127..43588 (462 bp)
Type: Others
Protein ID: WP_137119371.1
Location: 43595..44038 (444 bp)
Type: Others
Protein ID: WP_001129679.1
Location: 44038..44418 (381 bp)
Type: Others
Protein ID: WP_045193734.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
E4414_RS2167534827..35438-612WP_017857624.1hypothetical protein-
E4414_RS2168035546..36007-462WP_000811790.1hypothetical protein-
E4414_RS2168536530..36730-201WP_017857623.1hypothetical protein-
E4414_RS2169036735..36896-162Protein_33BrnT family toxin-
E4414_RS2345037045..37191+147WP_167493406.1hypothetical protein-
E4414_RS2169537154..37879+726WP_000414903.1hypothetical protein-
E4414_RS2170037882..38223+342WP_000727287.1hypothetical protein-
E4414_RS2170538284..38550+267WP_000844450.1hypothetical protein-
E4414_RS2171038550..38933+384WP_000617796.1hypothetical protein-
E4414_RS2171539001..39342-342WP_000240418.1endoribonuclease MazFToxin
E4414_RS2172039336..39572-237WP_000443825.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
E4414_RS2172539912..40919-1008WP_000628975.1hypothetical protein-
E4414_RS2173041255..41443-189WP_000425065.1hypothetical protein-
E4414_RS2173541613..41828-216WP_017857593.1hypothetical protein-
E4414_RS2174041818..42258-441WP_001289702.1hypothetical protein-
E4414_RS2174542255..42488-234WP_000416314.1hypothetical protein-
E4414_RS2175542693..43127-435WP_061226524.1M15 family metallopeptidase-
E4414_RS2176043127..43588-462WP_137119371.1hypothetical protein-
E4414_RS2176543595..44038-444WP_001129679.1hypothetical protein-
E4414_RS2177044038..44418-381WP_045193734.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..129376129376


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-112)

Antitoxin

Antitoxin PemI-like

(1-78)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12918.12 Da        Isoelectric Point: 9.9595

>T123720 WP_000240418.1 NZ_CP039285:c39342-39001 [Leptospira interrogans]
MVKNRNYTPEKGDIVWLNFTPQAGHEQKGRRPALVLSPKEYNSKTGLAIFCPITSKIKGYPFEVLIKSKKIDGVILSDQV
KNLDWTIREAEFIESINKVSLKEVLDNIKLLIF

Download         Length: 342 bp

>T123720 NZ_CP039285:c39342-39001 [Leptospira interrogans]
TTGGTAAAGAATAGAAACTATACTCCTGAAAAAGGAGATATAGTGTGGTTGAACTTTACTCCTCAAGCAGGTCATGAACA
GAAAGGTCGTAGACCTGCACTTGTTTTATCGCCTAAGGAATATAATTCAAAGACAGGGTTAGCAATATTTTGTCCAATTA
CCAGTAAAATTAAAGGTTATCCATTCGAAGTGTTGATTAAATCAAAAAAAATCGATGGTGTAATTCTTTCTGATCAAGTA
AAAAACTTAGATTGGACTATCCGTGAAGCAGAATTTATTGAATCAATAAATAAAGTTTCTTTAAAAGAAGTTTTAGATAA
TATTAAATTATTAATATTCTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8728.95 Da        Isoelectric Point: 5.6663

>AT123720 WP_000443825.1 NZ_CP039285:c39572-39336 [Leptospira interrogans]
MESIIQKWGNSLGIRIPKAMATELELNDGSHVELQYEGDKIVIYPMKKASLEDKLSKITKQNLHSEISTGNSIGNEAW

Download         Length: 237 bp

>AT123720 NZ_CP039285:c39572-39336 [Leptospira interrogans]
ATGGAATCAATTATTCAAAAATGGGGTAATAGCTTAGGAATTAGAATTCCAAAAGCAATGGCAACGGAATTAGAGTTAAA
TGATGGAAGCCATGTTGAATTACAATATGAAGGAGATAAGATTGTAATATATCCAATGAAAAAAGCTTCATTGGAAGATA
AACTTTCTAAAATTACGAAACAAAATCTTCACTCTGAAATATCTACTGGTAATTCTATAGGCAATGAAGCTTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A4D8SL30

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0F6HC33

References