Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpIK/PemK(toxin)
Location 1328775..1329351 Replicon chromosome
Accession NZ_CP039283
Organism Leptospira interrogans strain FMAS_AW1

Toxin (Protein)


Gene name chpK Uniprot ID Q93MT8
Locus tag E4414_RS05630 Protein ID WP_000617906.1
Coordinates 1329010..1329351 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name chpI Uniprot ID Q93MT9
Locus tag E4414_RS05625 Protein ID WP_000844758.1
Coordinates 1328775..1329023 (+) Length 83 a.a.

Genomic Context

E4414_RS05610E4414_RS05620E4414_RS05625E4414_RS05630E4414_RS05650E4414_RS05655E4414_RS22975E4414_RS05635E4414_RS05640
Location: 1324427..1326409 (1983 bp)
Type: Others
Protein ID: WP_000802799.1
Location: 1327663..1327959 (297 bp)
Type: Others
Protein ID: WP_000477061.1
Location: 1328775..1329023 (249 bp)
Type: Antitoxin
Protein ID: WP_000844758.1
Location: 1329010..1329351 (342 bp)
Type: Toxin
Protein ID: WP_000617906.1
Location: 1333248..1333715 (468 bp)
Type: Others
Protein ID: WP_000060051.1
Location: 1333712..1334116 (405 bp)
Type: Others
Protein ID: WP_001974506.1
Location: 1327051..1327509 (459 bp)
Type: Others
Protein ID: WP_000453263.1
Location: 1330377..1331369 (993 bp)
Type: Others
Protein ID: WP_000041092.1
Location: 1331509..1332444 (936 bp)
Type: Others
Protein ID: WP_000004530.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
E4414_RS056101324427..1326409+1983WP_000802799.1HD family phosphohydrolase-
E4414_RS229751327051..1327509-459WP_000453263.1hypothetical protein-
E4414_RS056201327663..1327959+297WP_000477061.1helix-turn-helix domain-containing protein-
E4414_RS056251328775..1329023+249WP_000844758.1ribbon-helix-helix domain-containing proteinAntitoxin
E4414_RS056301329010..1329351+342WP_000617906.1type II toxin-antitoxin system PemK/MazF family toxinToxin
E4414_RS056351330377..1331369-993WP_000041092.1aldolase-
E4414_RS056401331509..1332444-936WP_000004530.1ornithine carbamoyltransferase-
E4414_RS056501333248..1333715+468WP_000060051.1hypothetical protein-
E4414_RS056551333712..1334116+405WP_001974506.1pyridoxamine 5'-phosphate oxidase family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(2-41)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12372.25 Da        Isoelectric Point: 6.3272

>T123719 WP_000617906.1 NZ_CP039283:1329010-1329351 [Leptospira interrogans]
MIRGEIWWVDLGIPFGSEPGFKRPVLIIQDDSFNQSNINTIVSIAITSNLNLSEAPGNVFISKKDSSLSKDSVINVSQIV
TLDKERFLNKAGKLKSNKLGEVEIGLKLVTGLD

Download         Length: 342 bp

>T123719 NZ_CP039283:1329010-1329351 [Leptospira interrogans]
ATGATTCGTGGTGAAATTTGGTGGGTAGACTTGGGAATTCCATTTGGAAGTGAGCCTGGATTTAAACGTCCAGTTCTTAT
AATTCAAGATGACTCTTTTAATCAAAGTAATATTAATACAATAGTTTCGATTGCAATTACATCGAATTTAAATCTATCTG
AAGCACCAGGTAATGTTTTCATTAGTAAAAAAGATTCGAGTTTATCAAAGGACTCGGTCATAAATGTTTCTCAAATTGTG
ACTTTAGATAAAGAAAGATTTCTTAACAAAGCGGGTAAACTTAAATCAAATAAATTAGGTGAAGTTGAAATTGGGCTTAA
GTTGGTTACAGGCTTAGATTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9380.77 Da        Isoelectric Point: 10.3815

>AT123719 WP_000844758.1 NZ_CP039283:1328775-1329023 [Leptospira interrogans]
MKTAISIPDELFRAAEKIAKKLGIPRSQLFAKALEEFIQSHSKESVTEKLNKIYSNKSKETRNNITDLSVESLRKSLKND
SW

Download         Length: 249 bp

>AT123719 NZ_CP039283:1328775-1329023 [Leptospira interrogans]
ATGAAGACGGCGATTTCAATTCCTGATGAGTTATTTAGGGCTGCCGAGAAAATAGCTAAAAAACTTGGGATTCCTCGAAG
CCAGTTATTTGCAAAAGCATTAGAAGAATTTATCCAATCTCATAGTAAAGAATCTGTAACTGAGAAATTAAATAAAATCT
ACAGTAATAAATCCAAAGAAACTAGAAATAATATTACTGACTTATCCGTAGAATCGCTTCGTAAGAGTTTAAAAAATGAT
TCGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0M4MS74

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0F6HD92

References