Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-VagC
Location 903149..903777 Replicon chromosome
Accession NZ_CP039283
Organism Leptospira interrogans strain FMAS_AW1

Toxin (Protein)


Gene name vapC Uniprot ID Q8F7E4
Locus tag E4414_RS03850 Protein ID WP_000281042.1
Coordinates 903149..903547 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q8F7E3
Locus tag E4414_RS03855 Protein ID WP_001192482.1
Coordinates 903547..903777 (-) Length 77 a.a.

Genomic Context

E4414_RS03825E4414_RS03830E4414_RS03875E4414_RS03835E4414_RS03840E4414_RS03845E4414_RS03850E4414_RS03855E4414_RS03860E4414_RS03865E4414_RS03870E4414_RS03880
Location: 898441..899208 (768 bp)
Type: Others
Protein ID: WP_017857864.1
Location: 899749..900609 (861 bp)
Type: Others
Protein ID: WP_000682231.1
Location: 906061..907605 (1545 bp)
Type: Others
Protein ID: WP_017857865.1
Location: 900825..901283 (459 bp)
Type: Others
Protein ID: WP_001239004.1
Location: 901284..902360 (1077 bp)
Type: Others
Protein ID: WP_001170569.1
Location: 902503..903051 (549 bp)
Type: Others
Protein ID: WP_000479564.1
Location: 903149..903547 (399 bp)
Type: Toxin
Protein ID: WP_000281042.1
Location: 903547..903777 (231 bp)
Type: Antitoxin
Protein ID: WP_001192482.1
Location: 904068..904547 (480 bp)
Type: Others
Protein ID: WP_002108895.1
Location: 904584..904925 (342 bp)
Type: Others
Protein ID: WP_000611885.1
Location: 905134..906024 (891 bp)
Type: Others
Protein ID: WP_000789618.1
Location: 907931..908521 (591 bp)
Type: Others
Protein ID: WP_000437520.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
E4414_RS03825898441..899208+768WP_017857864.1DUF1554 domain-containing protein-
E4414_RS03830899749..900609+861WP_000682231.1hypothetical protein-
E4414_RS03835900825..901283-459WP_001239004.1GNAT family N-acetyltransferase-
E4414_RS03840901284..902360-1077WP_001170569.1hypothetical protein-
E4414_RS03845902503..903051-549WP_000479564.1hypothetical protein-
E4414_RS03850903149..903547-399WP_000281042.1type II toxin-antitoxin system VapC family toxinToxin
E4414_RS03855903547..903777-231WP_001192482.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
E4414_RS03860904068..904547-480WP_002108895.1hypothetical protein-
E4414_RS03865904584..904925-342WP_000611885.1hypothetical protein-
E4414_RS03870905134..906024-891WP_000789618.1hypothetical protein-
E4414_RS03875906061..907605+1545WP_017857865.1YceK/YidQ family lipoprotein-
E4414_RS03880907931..908521-591WP_000437520.1energy transducer TonB-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15139.76 Da        Isoelectric Point: 9.6893

>T123718 WP_000281042.1 NZ_CP039283:c903547-903149 [Leptospira interrogans]
MYLLDTNICIFLIKKKNATLLENLKKKLNKDLFVSSLTVAELEFGIQKSEFKEKNKVALIEFLTIFNILSFSDKDAESYG
IIRADLERKGNVIGSIDMLLAAQAIANNYIFVTNNTKEFKRIKALKIENWTQ

Download         Length: 399 bp

>T123718 NZ_CP039283:c903547-903149 [Leptospira interrogans]
ATGTATCTTTTGGATACCAATATATGCATTTTTCTAATTAAAAAGAAAAATGCGACTCTGTTAGAAAATCTTAAGAAAAA
ATTAAATAAAGATCTATTTGTTTCGTCTTTAACTGTTGCGGAACTTGAGTTTGGAATTCAGAAAAGTGAATTTAAAGAAA
AGAATAAAGTTGCACTAATCGAATTTTTAACGATTTTCAATATACTTTCCTTTTCTGATAAAGATGCAGAGTCTTACGGT
ATCATCAGAGCGGATTTGGAGAGGAAAGGTAATGTAATCGGTTCAATAGACATGTTACTTGCCGCTCAAGCAATTGCTAA
TAATTATATCTTTGTTACTAATAATACAAAAGAATTTAAAAGAATTAAGGCTTTAAAAATAGAAAATTGGACACAATAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8771.05 Da        Isoelectric Point: 8.6588

>AT123718 WP_001192482.1 NZ_CP039283:c903777-903547 [Leptospira interrogans]
MQTAKLFINGRSQAVRLPKEFQFTGDDVLIQKVGEAVILVPKNKAWNVFLEGLNGFSDDFFKEEREQPKSDKREKL

Download         Length: 231 bp

>AT123718 NZ_CP039283:c903777-903547 [Leptospira interrogans]
ATGCAAACAGCCAAATTATTTATAAATGGAAGAAGTCAAGCGGTCAGATTACCAAAAGAATTTCAATTTACCGGAGATGA
TGTTCTCATTCAAAAAGTCGGAGAGGCGGTAATATTGGTTCCGAAAAACAAGGCCTGGAACGTATTTTTAGAAGGATTGA
ACGGGTTTTCAGATGATTTCTTTAAGGAGGAGAGAGAACAGCCGAAATCTGATAAAAGAGAAAAGCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0F6HAN6

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0F6HAF7

References